Figure 1
From: Regulation of gene expression by FSP27 in white and brown adipose tissue
Dramatically altered transcriptional network in the WAT from FSP27- deficient mice by microarray analysis. A) The most significant up-regulated and down-regulated pathways in the WAT of FSP27-null mice were identified using Gene Set Enrichment Analysis (GSEA). The last number of each pathway represents the total number of genes in one gene set. The middle number represents the number of genes with an altered expression pattern (using the criteria described above), and the first number represents the number of up-regulated or down-regulated genes in the gene set. B) The pathways that were significantly up-regulated, as revealed by enrichment plot analysis, were the Krebs-TCA cycle, the electron transport chain and the mitochondrial fatty acid β oxidation pathway. The denotation of the numbers in this figure is as follows: The number of genes having a higher than 20.5-fold increase (the number of genes having a higher than 1-fold increase in expression)/the number of genes with an altered expression pattern as determined by microarray in the WAT of Fsp27-/- mice (total number of genes detected by the microarray)/total number of genes in a specific pathway.