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Table 1 Candidate genes resulting from microarray studies comparing FVB/N Prnp-/- versus FVB/N mice.

From: Brain transcriptional stability upon prion protein-encoding gene invalidation in zygotic or adult mouse

Genes FVB/N Prnp-/- FVB/N Prnp-/- Protein
  Microarray QPCR  
  (Log2 ratio) (ΔΔ CT)  
Downregulated    
Prnp -1.63 -15 Prion protein or PrPc
Scg5 -1.37 -2.13 Neuroendocrine secretory protein 7B2
Upregulated    
None    
  1. Differentially expressed genes detected by the microarray analysis are listed with the calculated differential ratio (log2) alongside the observed delta-delta CT resulting from the QPCR experiment. The comparative Ct method is known as the 2 [delta][delta]Ct method, where delta delta Ct = [delta]Ct, sample - [delta]Ct, reference