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Table 3 Differentially expressed genes detected at 10 weeks by microarray studies comparing Tg37+/- NFH-Cre-/- and Tg37+/- NFH-Cre+/- brain tissues.

From: Brain transcriptional stability upon prion protein-encoding gene invalidation in zygotic or adult mouse

Microarray ID Locus Name Ratio (log2) Bonf Pval Top Functions
301955 Atp13a1 0,81 2,90E-09 Response to oxidative stress
217673 A630023P12Rik -0,62 3,16E-04 Unknown
250792 Txnl2 -0,60 8,65E-04 Cardiovascular system development, Neuronal differentiation
262559 Zfp819 -0,58 2,89E-03 Embryonic Development
203516 Sepx1 -0,56 7,29E-03 Genetic Disorder
284620 Slc8a1 -0,54 1,74E-02 Response to oxidative stress
235326 Kcnj5 -0,54 2,31E-02 Cell Death, Neurological Disease, Nervous System Development and Function
202068 1810030J14Rik -0,53 3,99E-02 Cancer, Cell death
268919 A130070M06 -0,52 4,95E-02 Ribosome release
253726 Synaptotagmin11 0,52 4,38E-02 Synaptic vesicle trafficking, Nervous system function, Response to oxidative Stress
247145 0610038F07Rik 0,58 3,43E-03 Mitochondrial function
  1. Differentially expressed genes detected by the microarray analysis are listed with the calculated differential ratios (log2) and the Bonferroni p values (Bonf Pval). The top functions were deduced either using the Ingenuity pathways analysis software http://www.ingenuity.com or by looking at the expression pattern and putative functions attributed to those genes (italized annotations). Italic names: genes potentially involved in cellular development and differentiation. Bold-faced type names: genes potentially involved in cell death and disorders, including response to oxidative stress. Italic and bold-faced type names: genes potentially involved in both sets of functions.
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BMC Genomics

ISSN: 1471-2164

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