Brain transcriptional stability upon prion protein-encoding gene invalidation in zygotic or adult mouse

BMC Genomics

Table 3 Differentially expressed genes detected at 10 weeks by microarray studies comparing Tg37^+/^- NFH-Cre^-/^- and Tg37^+/^- NFH-Cre^+/^- brain tissues.

Microarray ID	Locus Name	Ratio (log2)	Bonf Pval	Top Functions
301955	Atp13a1	0,81	2,90E-09	Response to oxidative stress
217673	A630023P12Rik	-0,62	3,16E-04	Unknown
250792	Txnl2	-0,60	8,65E-04	Cardiovascular system development, Neuronal differentiation
262559	Zfp819	-0,58	2,89E-03	Embryonic Development
203516	Sepx1	-0,56	7,29E-03	Genetic Disorder
284620	Slc8a1	-0,54	1,74E-02	Response to oxidative stress
235326	*Kcnj5*	-0,54	2,31E-02	Cell Death, Neurological Disease, Nervous System Development and Function
202068	1810030J14Rik	-0,53	3,99E-02	Cancer, Cell death
268919	A130070M06	-0,52	4,95E-02	Ribosome release
253726	*Synaptotagmin11*	0,52	4,38E-02	Synaptic vesicle trafficking, Nervous system function, Response to oxidative Stress
247145	0610038F07Rik	0,58	3,43E-03	Mitochondrial function

Differentially expressed genes detected by the microarray analysis are listed with the calculated differential ratios (log2) and the Bonferroni p values (Bonf Pval). The top functions were deduced either using the Ingenuity pathways analysis software http://www.ingenuity.com or by looking at the expression pattern and putative functions attributed to those genes (italized annotations). Italic names: genes potentially involved in cellular development and differentiation. Bold-faced type names: genes potentially involved in cell death and disorders, including response to oxidative stress. Italic and bold-faced type names: genes potentially involved in both sets of functions.

ISSN: 1471-2164