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Table 3 Differentially expressed genes detected at 10 weeks by microarray studies comparing Tg37+/- NFH-Cre-/- and Tg37+/- NFH-Cre+/- brain tissues.

From: Brain transcriptional stability upon prion protein-encoding gene invalidation in zygotic or adult mouse

Microarray ID Locus Name Ratio (log2) Bonf Pval Top Functions
301955 Atp13a1 0,81 2,90E-09 Response to oxidative stress
217673 A630023P12Rik -0,62 3,16E-04 Unknown
250792 Txnl2 -0,60 8,65E-04 Cardiovascular system development, Neuronal differentiation
262559 Zfp819 -0,58 2,89E-03 Embryonic Development
203516 Sepx1 -0,56 7,29E-03 Genetic Disorder
284620 Slc8a1 -0,54 1,74E-02 Response to oxidative stress
235326 Kcnj5 -0,54 2,31E-02 Cell Death, Neurological Disease, Nervous System Development and Function
202068 1810030J14Rik -0,53 3,99E-02 Cancer, Cell death
268919 A130070M06 -0,52 4,95E-02 Ribosome release
253726 Synaptotagmin11 0,52 4,38E-02 Synaptic vesicle trafficking, Nervous system function, Response to oxidative Stress
247145 0610038F07Rik 0,58 3,43E-03 Mitochondrial function
  1. Differentially expressed genes detected by the microarray analysis are listed with the calculated differential ratios (log2) and the Bonferroni p values (Bonf Pval). The top functions were deduced either using the Ingenuity pathways analysis software or by looking at the expression pattern and putative functions attributed to those genes (italized annotations). Italic names: genes potentially involved in cellular development and differentiation. Bold-faced type names: genes potentially involved in cell death and disorders, including response to oxidative stress. Italic and bold-faced type names: genes potentially involved in both sets of functions.