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Table 4 Differentially expressed genes detected at 14 weeks by microarray studies comparing Tg37+/- NFH-Cre-/- and Tg37+/- NFH-Cre+/- brain tissues.

From: Brain transcriptional stability upon prion protein-encoding gene invalidation in zygotic or adult mouse

Microarray ID Locus Name Ratio (log2) Bonf Pval Top Functions
275404 EST1 (GenebankAV451297.1) -2,62 0,00E+00 Unknown (Embryonic Development)
197253 Ifitm3 -1,41 0,00E+00 DNA replication, Nervous System Development and Function
237827 AY036118 -1,19 0,00E+00 Eukaryotic polypeptide chain releasing factor
245680 4931406E20Rik -0,92 0,00E+00 Unknown
202068 1810030J14Rik -0,89 0,00E+00 Unknown (Cancer, Cell death)
196280 Prelid2 -0,81 1,40E-10 Cardiovascular Disease, Cellular Development, Embryonic Development
211028 4930428E07Rik -0,79 6,77E-10 Unknown (Reproductive System)
272796 6430604K15Rik -0,76 7,67E-09 Unknown (Zinc Finger protein)
312533 BM229693 -0,71 2,99E-07 Unknown (Embryonic Development)
231366 Tmem98 -0,69 7,27E-07 Unknown (Transmembrane protein)
242062 Sdccag3 -0,65 1,11E-05 Cancer, Cardiovascular System Development and Function, Reproductive system Disease
226542 Ifng -0,62 6,35E-05 Cardiovascular Disease, Cellular Development, Embryonic Development Cell Death, Neurological Disease, Nervous System
281732 Papss2 -0,60 1,62E-04 Development and Disease Cell Death, Neurological Disease, Nervous System
202885 Ramp1 -0,58 7,58E-04 Development and Disease
213956 9930022N03Rik -0,58 8,07E-04 Unknown (expressed in dendtritic cells)
253726 Synaptotagmin11 -0,56 1,77E-03 Synaptic vesicle trafficking, Nervous system function, Response to oxidative stress
218976 4833414E09Rik -0,55 3,39E-03 Unknown (expressed in skin and neonate head)
273728 Zbtb33 -0,55 3,81E-03 DNA replication, Nervous System Development and Function
277491 Adam24 -0,54 5,33E-03 Reproductive System Development and Function
300948 4930579C12Rik -0,54 5,41E-03 Unknown (Reproductive system)
207253 C330013F16Rik -0,54 7,11E-03 Unknown
279418 A530088H08Rik -0,53 8,21E-03 Unknown
287029 Fryl -0,53 9,99E-03 Cardiovascular Disease, Cellular Development, Embryonic Development
287258 Grin1 -0,52 1,26E-02 Carbohydrate metabolism, Lipid metabolism, Small molecule Biochemistry
312507 9030411K21Rik -0,51 2,50E-02 Unknown (Embryonic Development)
192336 BC043118 -0,50 3,79E-02 Unknown (Nervous System Development)
217372 Sec1 0,50 3,28E-02 Synaptic transmission and general secretion
241944 2810471M01Rik 0,51 2,15E-02 Unknown
214574 Cabp1 0,52 1,61E-02 Calcium transport, Response to oxidative stress
248843 T2bp 0,52 1,32E-02 Cell Death
240393 Nfe2 0,53 1,00E-02 DNA replication, Nervous System Development and Function
305580 Abcc12 0,53 9,52E-03 Cardiovascular Disease, Cellular Development, Embryonic Development
253103 Adck4 0,53 9,28E-03 Cardiovascular Disease, Cellular Development, Embryonic Development
235246 Cyp2d26 0,54 5,56E-03 Detoxification, Clearance of drugs
200884 Sall3 0,54 5,56E-03 Cancer, Cell growth and proliferation, Respiratory Disease
235326 Kcnj5 0,54 4,30E-03 Cell Death, Neurological Disease, Nervous System Development and Disease
187962 1700055C04Rik 0,56 2,11E-03 Unknown (Reproductive system)
310508 Arfgef2 0,56 1,79E-03 Cardiovascular Disease, Cellular Development, Embryonic Development
271541 Dusp4 0,56 1,56E-03 Carbohydrate metabolism, Lipid metabolism, Small molecule Biochemistry
189538 Hist2h3c1 0,57 1,29E-03 DNA replication, Nervous System Development and Function
192597 Grit 0,58 6,36E-04 Neural Development
273128 Nrbp2 0,59 2,86E-04 Embryonic mouse brain development, Neuronal differentiation
259059 Ralb 0,62 6,20E-05 Carbohydrate metabolism, Lipid metabolism, Small molecule Biochemistry
194060 Defb13 0,65 1,47E-05 Host's innate defense
197262 Sprr2g 0,67 3,88E-06 Cell Death, Neurological Disease, Nervous System Development and Disease
278391 1110038D17Rik 0,79 8,61E-10 Unknown (Embryonic Development)
284995 GeneBank A530045M11, AI604229, AA174363 0,81 1,62E-10 Unknown
  1. Differentially expressed genes detected by the microarray analysis are listed with the calculated differential ratios (log2) and the Bonferroni p values (Bonf Pval). The top functions were deduced either using the Ingenuity pathways analysis software http://www.ingenuity.com or by looking at the expression pattern and putative functions attributed to those genes (italized annotations). Italic names: genes potentially involved in cellular development and differentiation. Bold-faced type name: gene potentially involved in cell death and disorders, including response to oxidative stress. Italic and bold-faced type names: genes potentially involved in both sets of functions.
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BMC Genomics

ISSN: 1471-2164

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