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Table 4 Differentially expressed genes detected at 14 weeks by microarray studies comparing Tg37+/- NFH-Cre-/- and Tg37+/- NFH-Cre+/- brain tissues.

From: Brain transcriptional stability upon prion protein-encoding gene invalidation in zygotic or adult mouse

Microarray ID

Locus Name

Ratio (log2)

Bonf Pval

Top Functions

275404

EST1 (GenebankAV451297.1)

-2,62

0,00E+00

Unknown (Embryonic Development)

197253

Ifitm3

-1,41

0,00E+00

DNA replication, Nervous System Development and Function

237827

AY036118

-1,19

0,00E+00

Eukaryotic polypeptide chain releasing factor

245680

4931406E20Rik

-0,92

0,00E+00

Unknown

202068

1810030J14Rik

-0,89

0,00E+00

Unknown (Cancer, Cell death)

196280

Prelid2

-0,81

1,40E-10

Cardiovascular Disease, Cellular Development, Embryonic Development

211028

4930428E07Rik

-0,79

6,77E-10

Unknown (Reproductive System)

272796

6430604K15Rik

-0,76

7,67E-09

Unknown (Zinc Finger protein)

312533

BM229693

-0,71

2,99E-07

Unknown (Embryonic Development)

231366

Tmem98

-0,69

7,27E-07

Unknown (Transmembrane protein)

242062

Sdccag3

-0,65

1,11E-05

Cancer, Cardiovascular System Development and Function, Reproductive system Disease

226542

Ifng

-0,62

6,35E-05

Cardiovascular Disease, Cellular Development, Embryonic Development Cell Death, Neurological Disease, Nervous System

281732

Papss2

-0,60

1,62E-04

Development and Disease Cell Death, Neurological Disease, Nervous System

202885

Ramp1

-0,58

7,58E-04

Development and Disease

213956

9930022N03Rik

-0,58

8,07E-04

Unknown (expressed in dendtritic cells)

253726

Synaptotagmin11

-0,56

1,77E-03

Synaptic vesicle trafficking, Nervous system function, Response to oxidative stress

218976

4833414E09Rik

-0,55

3,39E-03

Unknown (expressed in skin and neonate head)

273728

Zbtb33

-0,55

3,81E-03

DNA replication, Nervous System Development and Function

277491

Adam24

-0,54

5,33E-03

Reproductive System Development and Function

300948

4930579C12Rik

-0,54

5,41E-03

Unknown (Reproductive system)

207253

C330013F16Rik

-0,54

7,11E-03

Unknown

279418

A530088H08Rik

-0,53

8,21E-03

Unknown

287029

Fryl

-0,53

9,99E-03

Cardiovascular Disease, Cellular Development, Embryonic Development

287258

Grin1

-0,52

1,26E-02

Carbohydrate metabolism, Lipid metabolism, Small molecule Biochemistry

312507

9030411K21Rik

-0,51

2,50E-02

Unknown (Embryonic Development)

192336

BC043118

-0,50

3,79E-02

Unknown (Nervous System Development)

217372

Sec1

0,50

3,28E-02

Synaptic transmission and general secretion

241944

2810471M01Rik

0,51

2,15E-02

Unknown

214574

Cabp1

0,52

1,61E-02

Calcium transport, Response to oxidative stress

248843

T2bp

0,52

1,32E-02

Cell Death

240393

Nfe2

0,53

1,00E-02

DNA replication, Nervous System Development and Function

305580

Abcc12

0,53

9,52E-03

Cardiovascular Disease, Cellular Development, Embryonic Development

253103

Adck4

0,53

9,28E-03

Cardiovascular Disease, Cellular Development, Embryonic Development

235246

Cyp2d26

0,54

5,56E-03

Detoxification, Clearance of drugs

200884

Sall3

0,54

5,56E-03

Cancer, Cell growth and proliferation, Respiratory Disease

235326

Kcnj5

0,54

4,30E-03

Cell Death, Neurological Disease, Nervous System Development and Disease

187962

1700055C04Rik

0,56

2,11E-03

Unknown (Reproductive system)

310508

Arfgef2

0,56

1,79E-03

Cardiovascular Disease, Cellular Development, Embryonic Development

271541

Dusp4

0,56

1,56E-03

Carbohydrate metabolism, Lipid metabolism, Small molecule Biochemistry

189538

Hist2h3c1

0,57

1,29E-03

DNA replication, Nervous System Development and Function

192597

Grit

0,58

6,36E-04

Neural Development

273128

Nrbp2

0,59

2,86E-04

Embryonic mouse brain development, Neuronal differentiation

259059

Ralb

0,62

6,20E-05

Carbohydrate metabolism, Lipid metabolism, Small molecule Biochemistry

194060

Defb13

0,65

1,47E-05

Host's innate defense

197262

Sprr2g

0,67

3,88E-06

Cell Death, Neurological Disease, Nervous System Development and Disease

278391

1110038D17Rik

0,79

8,61E-10

Unknown (Embryonic Development)

284995

GeneBank A530045M11, AI604229, AA174363

0,81

1,62E-10

Unknown

  1. Differentially expressed genes detected by the microarray analysis are listed with the calculated differential ratios (log2) and the Bonferroni p values (Bonf Pval). The top functions were deduced either using the Ingenuity pathways analysis software http://www.ingenuity.com or by looking at the expression pattern and putative functions attributed to those genes (italized annotations). Italic names: genes potentially involved in cellular development and differentiation. Bold-faced type name: gene potentially involved in cell death and disorders, including response to oxidative stress. Italic and bold-faced type names: genes potentially involved in both sets of functions.