Table 5 QPCR analysis of the expression of candidate genes resulting from microarray studies comparing Tg37xNFH-Cre versus Tg37 mice.
Genes | Tg37xNFH-Cre | Tg37xNFH-Cre | |
|---|---|---|---|
Microarray | QPCR | Protein | |
(log2 ratio) | (ΔΔ CT) | ||
10 weeks | |||
Glrx3 | -0.6 | 0.34 | glutaredoxin 3 |
Atp13a1 | 0.81 | -0.08 | ATPase type 13A1 |
Prnp Tg37 | ND | -5.62 | Prion protein |
14 weeks | |||
AV451297.1 | -2.62 | -0.02 | Hypothetical protein |
Ifitm3 | -1.41 | -0.12 | Interferon-induced transmembrane protein 3 |
Erf1 | -1.19 | -1.12 | Eukaryote class I release factor |
Bace1 | -0.48 | -0.02 | beta-site APP-cleaving enzyme 1 |
BB217622.2 | 0.81 | 0.64 | Unknown |
Riken D17 | 0.79 | 0.31 | Unknown |
Fgf2 | 0.48 | 0.47 | fibroblast growth factor 2 |
Prnp Tg37 | ND | -6.43 | Prion protein |