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Table 3 Clusters Feature Comparison

From: A systems approach to mapping transcriptional networks controlling surfactant homeostasis

Cluster name

Gene Number

Function and Process

Mouse Phenotype

Cell Components

C1

313

Lipid biosynthesis; Morphogenesis; Differentiation; Proliferation; Lung and respiratory tube development; Vascular development

Abnormal vasculature development; Abnormal cardiovascular physiology; Abnormal alveolar morphology; Abnormal respiratory mechanics

Insoluble fraction; Membrane fraction

C2

54

Lipid Metabolism; Lipid Transport

Abnormal respiratory alveolar morphology; Abnormal lipid homeostasis

Endoplasmic reticulum

C28

205

Response to external stimulus; Lipid metabolic process

Abnormal blood chemistry

Insoluble fraction; Integral to plasma membrane

  1. Genes from each cluster were subject to gene set enrichment analysis to identify enriched functions and processes, mouse phenotypes and cell components http://toppgene.cchmc.org/.
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BMC Genomics

ISSN: 1471-2164

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