Table 7 Functionality and subcellular location of selected genes

Elovl1

Elongation of very long chain fatty acid protein1

Expressed in lung type II cells. Endoplasmic Reticulum Membrane

Tissue-specific synthesis of very long fatty acids and sphingolipids. May catalyze the conversion of beta-ketoacyl CoA to beta-hydroxyacyl CoA or Reduction of trans-2-enoyl CoA to the saturated acyl CoA derivative.

Parkinson's disease

Slc34a2

Solute carrier family 34 (sodium phosphate), Member 2

Apical Membrane of Type II cells

Actively transporting phosphate into cells via Na+ cotransport. May have a role in the synthesis of surfactant in lungs' alveoli.

pulmonary alveolar microlithiasis, ovarian cancer

Soat1 (Acat)

Sterol O-acyltransferase 1

Expressed in lung type II cells. Endoplasmic Reticulum Membrane

Catylyzes the formation of fatty acid-cholesterol esters. Plays a role in lipoprotein assembly and dietary cholesterol absorption.

atherosclerosis

Zdhhc3 (Godz)

Palmitoyltransferase Zinc finger DHHC domain-containing protein 3

Expressed in lung type II cells. Golgi apparatus

Palmitoyltransferase with broad specificity; membrane protein trafficking

Lpcat1 (Atyl2)

Acyltransferase-like 2 Phosphonoformate immuno-associated protein 3

Expressed in lung type II cells. Endoplasmic Reticulum and Golgi Apparatus Membrane

Mediates the conversion of 1-acyl-sn-glycero-3-phosphocholine (LPC) into phosphatidylcholine (PC). May synthesize phosphatidylcholine in pulmonary surfactant, play a pivotal role in respiratory physiology.

migraines

Stard4

START domain-containing protein 4

Expressed in lung type II cells. Mitochondria.

May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols

Huntington's disease

Dlk1 (DLK)

Protein delta homolog 1

Expressed in lung type II cells. Membrane

May function in adipocyte differentiation and in neuroendocrine differentiation

lung cancer, bronchiolo-alveolar adenocarcinoma, blepharophimosis, obesity, neoplasia, hypertriglyceridemia

Prdx6

Peroxiredoxin 6

Expressed in lung type II cells. Cytoplasm, Lysosome, lung secretory organelles.

Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury

acute allergic pulmonary eosinophilia, asthma, follicular adenoma, Huntington's disease, neoplasia

Abca3

ATP-binding cassette, sub-family A (ABC1), member 3

Expressed in lung type II cells. Membrane

Plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol

surfactant metabolism dysfunction, inflation, respiratory failure, atelectasis