Figure 1

Nuclear mt genes with T-DMRs identified by D-REAM analysis. (A) Differential methylation levels of HpyCH4IV sites for which the relative hypomethylation levels were analyzed using the D-REAM analysis. For each HpyCH4IV site, the corresponding MATscore is indicated along the horizontal axis. In each tissue comparison, the lowest MATscore of the HpyCH4IV sites whose hypomethylation were confirmed using COBRA, was considered as a threshold value for detecting hypomethylated regions in the tissue comparison. Pale-colored circles indicate that the corresponding HpyCH4IV site was not included in the hypo T-DMRs (see text for definition). (B) Matrices show the differential level of DNA methylation of the liver-, brain-, and heart-hypo T-DMRs in the tissues relative to the respcective methylation level of hypo T-DMRs in the liver, brain, and heart, respectively. Each column represents a different hypo T-DMR. The names of nuclear mt genes containing hypo T-DMRs in their TSS flanking regions are displayed under each column. (C) Number of nuclear mt genes with T-DMRs. Matrix columns represent different nuclear mt genes. (D) Function of nuclear mt genes, nuclear mt genes with T-DMRs and nuclear mt genes with liver-hypo T-DMRs. Pie charts illustrate the percentage of genes that possess the indicated functions.