DNA methylation status of nuclear-encoded mitochondrial genes underlies the tissue-dependent mitochondrial functions

Table 1 Nuclear mt genes with hypo T-DMRs

	Liver-hypo T-DMRs	Brain-hypo T-DMRs	Heart-hypo T-DMRs
Various mitochondrial functions
Metabolism	Abat, Acsl5, Oat, etc	Dmgdh, Mthfd1, Star, etc	Cpt1b, Efta, Pdk4, etc
Respiratory chain	Atp5o, Ndufb2, etc	Atp5l, Cox6, Ndufs8, etc	Atp5l, Ndufs4, Sdhc, etc
TCA cycle	Dlst	Aco2, Dlst	Ogdh
Detoxification	Gsr, Hagh, Mgst1, Tst	Gstk1
Tissue-specific mitochondrial functions	Otc, Lrpprc
Protein sorting	Immp1l	Tomm7
Regulation of mitochondrial morphology		Mfn1, Prelid1
Regulation of mtDNA	Peo1
Translation of mtDNA-encoded proteins	Lrpprc	Mtif2, Mtif3	Mrrf, Tufm

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