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Table 5 Power and proportion of false positive comparison of the KWII to MDR.

From: Comparison of information-theoretic to statistical methods for gene-gene interactions in the presence of genetic heterogeneity

Model α Interaction 1 Interactions 1 & 2* MDR PFP
   KWII MDR KWII MDR  
  0.01 98.7 19.9 98.1 0.7 0.0047
1-GH 0.001 94.3 1.3 89.4 0.9 0.0003
  0.0001 85.6 0.6 72.9 0.4 0.0002
2-GH 0.01 100 36.0 100 61.7 0.0116
  0.001 99.7 12.2 99.5 33.9 0.0029
  0.0001 98.1 5.0 96.3 23.3 0.0013
3 0.01 100 91.3 - - 0.0254
  0.001 100 56.1 - - 0.0112
  0.0001 100 33.1 - - 0.0067
3-GH 0.01 58.3 5.3 32.3 1.5 0.0028
  0.001 28.2 1.4 8.2 0.6 0.0010
  0.0001 15.3 0.1 2.2 0.3 0.0001
4 0.01 99.6 54.0 - - 0.0164
  0.001 97.5 8.0 - - 0.0042
  0.0001 91.5 0.5 - - 0.0010
4-GH 0.01 48.2 0.7 22.1 2.0 0.0019
  0.001 19.6 0 3.4 0.6 0.0005
  0.0001 9.1 0 0.9 0.3 0.0001
  1. *Models 3 and 4 had only a two SNP interaction (Interaction 1) present and thus power values are not applicable.
  2. The simulations are based on models in [16].
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BMC Genomics

ISSN: 1471-2164

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