Comparison of information-theoretic to statistical methods for gene-gene interactions in the presence of genetic heterogeneity

Table 5 Power and proportion of false positive comparison of the KWII to MDR.

Model	α	Interaction 1		Interactions 1 & 2*		MDR PFP
		KWII	MDR	KWII	MDR
	0.01	98.7	19.9	98.1	0.7	0.0047
1-GH	0.001	94.3	1.3	89.4	0.9	0.0003
	0.0001	85.6	0.6	72.9	0.4	0.0002
2-GH	0.01	100	36.0	100	61.7	0.0116
	0.001	99.7	12.2	99.5	33.9	0.0029
	0.0001	98.1	5.0	96.3	23.3	0.0013
3	0.01	100	91.3	-	-	0.0254
	0.001	100	56.1	-	-	0.0112
	0.0001	100	33.1	-	-	0.0067
3-GH	0.01	58.3	5.3	32.3	1.5	0.0028
	0.001	28.2	1.4	8.2	0.6	0.0010
	0.0001	15.3	0.1	2.2	0.3	0.0001
4	0.01	99.6	54.0	-	-	0.0164
	0.001	97.5	8.0	-	-	0.0042
	0.0001	91.5	0.5	-	-	0.0010
4-GH	0.01	48.2	0.7	22.1	2.0	0.0019
	0.001	19.6	0	3.4	0.6	0.0005
	0.0001	9.1	0	0.9	0.3	0.0001

*Models 3 and 4 had only a two SNP interaction (Interaction 1) present and thus power values are not applicable.
The simulations are based on models in [16].

ISSN: 1471-2164