|
Interaction
|
Sample Size
|
α
|
Power %
|
|---|
| | | |
KWII
|
MDR
|
RPM
|
Logistic
|
|---|
|
Interaction 1
|
600
|
0.001
|
68.9
|
7.8
|
48.8
|
68.3
|
| | |
0.0001
|
42.2
|
3.7
|
29.5
|
43.3
|
| |
1200
|
0.001
|
98.9
|
39.1
|
94.9
|
99.1
|
| | |
0.0001
|
95.6
|
10.0
|
87.8
|
95.4
|
| |
2400
|
0.001
|
100
|
65.3
|
100
|
100
|
| | |
0.0001
|
100
|
13.8
|
100
|
100
|
|
Interaction 3
|
600
|
0.001
|
15.1
|
0.04
|
7.2
|
14.8
|
| | |
0.0001
|
4.8
|
0.03
|
3.2
|
5.2
|
| |
1200
|
0.001
|
47.6
|
3.6
|
28.1
|
48.7
|
| | |
0.0001
|
26.6
|
0.04
|
15.2
|
24.6
|
| |
2400
|
0.001
|
95.1
|
6.6
|
84.4
|
94.0
|
| | |
0.0001
|
83.5
|
0.05
|
70.8
|
84.2
|
|
All 3 Interactions
|
600
|
0.001
|
7.6
|
0.01
|
2.2
|
7.5
|
| | |
0.0001
|
15.2
|
0.01
|
0.5
|
14.1
|
| |
1200
|
0.001
|
48.1
|
0.03
|
25.7
|
47.8
|
| | |
0.0001
|
26.6
|
0.01
|
11.5
|
22.1
|
| |
2400
|
0.001
|
95.1
|
2.9
|
84.4
|
94.0
|
| | |
0.0001
|
83.5
|
0.01
|
70.8
|
84.2
|
|
Interaction
|
Sample Size
|
α*
|
Proportion of False Positives
|
| | | |
KWII
|
MDR
|
RPM
|
Logistic
|
|
All 3 Interactions
|
600
|
0.001
|
-
|
0.0021
|
0.0010
|
0.0013
|
| | |
0.0001
|
-
|
0.0010
|
0.0001
|
0.0001
|
| |
1200
|
0.001
|
-
|
0.0075
|
0.0013
|
0.0016
|
| | |
0.0001
|
-
|
0.0011
|
0.0003
|
0.0002
|
| |
2400
|
0.001
|
-
|
0.0103
|
0.0009
|
0.0013
|
| | |
0.0001
|
-
|
0.0014
|
0.0002
|
0.0002
|
- *α is calibrated to the empirical false positive rate of KWII.
- The model used for the simulations contained three interacting pairs of SNP as summarized in Table 1: Interaction 1 and Interaction 2 in were based on [16] whereas Interaction 3 was based on [2].
