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Figure 6 | BMC Genomics

Figure 6

From: Identification of response-modulated genetic interactions by sensitivity-based epistatic analysis

Figure 6

Inference of functional modules and complexes relationships. (a) Hierarchical clustering of S-score profiles. Red bars indicate genes in the Rad5 epistasis group, members of the Shu complex, the Rad51-dependent and independent branches of the Rad52 epistasis group, members of the Mms22-dependent pathway and the Mms4/Mus81 endonuclease complex. The orange bar highlights the clustering of genes in the Shu complex with the Rad51-dependent pathway and Sgs1 (see text for details). Grey squares indicate double mutants not assayed. (b) Comparison of true positive and false positive rates for fitness- and sensitivity-based identification obtained by varying the threshold (Δ thr ) used to establish equivalence between single- and double-deletion phenotypes (see text). (c) Comparison of true positive rates for fitness- and sensitivity-based identification at different values of the equivalence threshold.

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