Inference of functional modules and complexes relationships. (a) Hierarchical clustering of S-score profiles. Red bars indicate genes in the Rad5 epistasis group, members of the Shu complex, the Rad51-dependent and independent branches of the Rad52 epistasis group, members of the Mms22-dependent pathway and the Mms4/Mus81 endonuclease complex. The orange bar highlights the clustering of genes in the Shu complex with the Rad51-dependent pathway and Sgs1 (see text for details). Grey squares indicate double mutants not assayed. (b) Comparison of true positive and false positive rates for fitness- and sensitivity-based identification obtained by varying the threshold (Δ
) used to establish equivalence between single- and double-deletion phenotypes (see text). (c) Comparison of true positive rates for fitness- and sensitivity-based identification at different values of the equivalence threshold.