Differential functional genomic effects of anti-inflammatory phytocompounds on immune signaling

BMC Genomics

Table 1 Genes down-regulated ≥3-fold by shikonin or emodin at 0.5 hours.

			Gene Expression Ratio (Test + LPS): LPS only
	Gene Symbol	Gene ID	shikonin	emodin	cytopiloyne	BF/S+L/Ep
Cytokines	IL1B	3553	0.32	0.35	0.59	0.59
	IL4	3565	0.25	0.2	0.92	0.81
	IL13	3596	0.36	0.33	0.6	0.71
	IRF1	3659	0.23	0.36	1.52	0.7
	KITLG	4254	0.31	0.34	1.03	0.74
	TNF	7124	0.24	0.68	0.38	0.85
	TNFSF9	8744	0.34	0.32	0.62	0.8
Chemotaxis & Cell Migration	CDH12	1010	0.22	0.34	0.23	0.45
	CCR2	1231	0.24	0.17	0.82	0.88
	CCR3	1232	0.26	0.38	0.49	0.55
	CCR4	1233	0.29	0.35	1.01	0.86
	CCBP2	1238	0.28	0.48	0.44	0.56
	ICAM2	3384	0.29	0.28	0.73	0.79
	ITGAE	3682	0.34	0.32	0.55	0.59
	CCL4	6351	0.3	0.64	0.49	0.87
	CCL8	6355	0.33	0.35	1.03	0.81
	CCL22	6367	0.27	0.28	0.72	0.64
	SELL	6402	0.26	0.91	0.58	1.15
	SELP	6403	0.24	0.18	0.44	0.57
	CXCR4	7852	0.39	0.19	0.59	1.26
	CD207	50489	0.26	0.41	0.6	0.67
	CLEC4A	50856	0.49	0.33	0.68	0.89
	CLEC1A	51267	0.3	0.47	0.32	0.54
Inflammatory Responses	CD1D	912	0.36	0.18	0.52	0.91
	CD80	941	0.31	0.39	0.33	0.52
	CSF3R	1441	0.49	0.33	0.69	0.82
	IL2RA	3559	0.25	0.23	0.95	0.86
	IL8RB	3579	0.27	0.34	0.64	0.53
	LIFR	3977	0.27	0.48	0.32	0.6
	MAP3K3	4215	0.3	0.27	0.78	0.73
	NFATC3	4775	0.18	0.06	0.8	1.15
	MAPK7	5598	0.28	0.26	1.09	0.66
	PTGS1	5742	0.36	0.3	0.72	0.82
	PTGS2	5743	0.25	0.17	1.03	0.93
	SLAMF1	6504	0.33	0.58	0.37	0.67
	STAT1	6772	0.29	0.2	1.04	0.8
	LILRB4	11006	0.18	0.16	0.94	0.78
Other	BCL2	596	0.32	0.4	0.7	0.65
	BCL2L1	598	0.31	0.31	0.98	0.61
	ETS1	2113	0.35	0.17	0.91	0.84
	FUT7	2529	0.35	0.32	0.78	0.57
	NR3C2	4306	0.33	0.48	0.89	0.66
	NGFR	4804	0.32	0.34	0.73	0.68
	TAP2	6891	0.2	0.14	0.72	0.85
	TFRC	7037	0.29	0.37	1.01	0.72

ISSN: 1471-2164