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Table 3 Genes down regulated ≥3-fold by BF/S+L/Ep or cyotpiloyne at 12 hours.

From: Differential functional genomic effects of anti-inflammatory phytocompounds on immune signaling

   

Gene Expresion Ratio (Test + LPS): LPS only

 

Gene Symbol

Gene ID

shikonin

emodin

cytopiloyne

BF/S+L/Ep

Cytokines

IL4

3565

1.12

0.94

0.68

0.25

 

IRF1

3659

2.01

0.87

0.78

0.27

 

TNFRSF11B

4982

0.93

0.81

0.66

0.26

 

TNFRSF10C

8794

1.04

0.96

0.86

0.32

Chemotaxis & Cell Migration

CDH1

999

1.07

0.81

0.74

0.27

 

CDH12

1010

0.6

0.49

0.53

0.17

 

CCR2

1231

1.24

1.17

0.45

0.28

 

CCR3

1232

1.06

0.68

0.57

0.25

 

CCBP2

1238

0.98

0.83

0.69

0.22

 

ITGA2

3673

0.96

0.77

0.69

0.28

 

ITGB1

3688

0.9

1.69

0.72

0.32

 

CCL2

6347

0.7

0.7

0.29

0.7

 

CXCR4

7852

1.04

1.69

0.6

0.32

Inflammatory Responses

CD80

941

1.71

1.09

0.55

0.3

 

GATA3

2625

1.15

0.88

0.72

0.26

 

IL7R

3575

1.67

0.88

0.73

0.3

 

IL8RB

3579

0.83

0.64

0.62

0.26

 

ITK

3702

1.07

0.95

0.79

0.3

 

LIFR

3977

1

0.84

0.74

0.27

 

NFATC3

4775

2.07

3.11

0.67

0.32

 

MAP2K5

5607

1.31

1.03

0.65

0.33

 

PTGS2

5743

1.26

0.97

0.63

0.29

 

SLAMF1

6504

1.04

0.74

0.59

0.3

 

IGSF6

10261

0.58

0.87

0.33

0.67

 

NFATC2IP

84901

1.1

0.78

0.66

0.22

Other

ANXA3

306

0.97

0.88

0.65

0.33

 

BCL2

596

1.05

1.19

0.87

0.29

 

MPO

4353

0.84

0.77

0.68

0.27

 

C1orf61

10485

1.19

1.02

0.7

0.31

 

CLEC1A

51267

0.8

0.69

0.6

0.25