Figure 3
From: Genome-wide conserved consensus transcription factor binding motifs are hyper-methylated
Predicted TFBS with conserved consensus motifs are hyper-methylated unless they are also biologically proven TFBS (empirical TFBS). Aggregate methylation profiles for predicted TFBS with conserved consensus motifs for a subset of 17 transcription factor families are hyper-methylated in hearts (A) and sperm (B) (N = 771,221); but hypo-methylated if they are also biologically proven TFBS (empirical TFBS by ChIP-seq; "set 4", N = 40,876) (C: hearts and D: sperm).