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Table 4 Enriched canonical signaling and metabolic pathways in OS epithelial regions

From: Comparative transcriptional profiling of the limbal epithelial crypt demonstrates its putative stem cell niche characteristics

Canonical metabolic pathways P-Value No of genes
LEC   
Oxidative Phosphorylation 4.52E-17 29
Ubiquinone biosynthesis 8.04E-12 14
Purine metabolism 0.00166 18
Pyrimidine metabolism 0.0274 9
Limbus   
Pentose Phosphate Pathway 0.0014 5
Oxidative Phosphorylation 0.00795 7
Valine, Leucine and Isoleucine Biosynthesis 0.00851 2
Alanine and aspartate metabolism 0.0151 3
Glycolysis/gluconeogenesis 0.047 4
Cornea   
Oxidative Phosphorylation 3.48E-21 41
Ubiquinone Biosynthesis 2.14E-08 16
Purine metabolism 0.000118 30
Alanine and Aspartate metabolism 0.000869 9
Glutathione metabolism 0.00607 8
Glycolysis/gluconeogenesis 0.00855 12
Lysine biosynthesis 0.0402 2
Citrate cycle 0.042 4
Pyruvate metabolism 0.0451 8
Canonical Signaling Pathways   
LEC   
NRF2-mediated Oxidative Stress Response 2.29E-05 16
Nucleotide Excision Repair Pathway 3.17E-05 7
Protein Ubiquitination Pathway 2.06E-05 16
Estrogen Receptor Signaling 8.79E-03 8
Glucocorticoid Receptor Signaling 1.81E-02 13
Limbus   
NRF2-mediated Oxidative Stress Response 2.81E-02 7
Regulation of actin based motility by Rho 4.51E-02 4
Cornea   
NRF2 mediated Oxidative Stress Response 2.51E-04 21
Protein Ubiquitination Pathway 3.09E-07 26
Estrogen Receptor Signaling 3.67E-04 15
Antigen Presentation Pathway 1.29E-03 7
VDR/RXR Activation 6.31E-03 10
Glucocorticoid Receptor Signaling 3.05E-02 20
Nucleotide Excision repair 2.77E-04 8