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Table 4 Enriched canonical signaling and metabolic pathways in OS epithelial regions

From: Comparative transcriptional profiling of the limbal epithelial crypt demonstrates its putative stem cell niche characteristics

Canonical metabolic pathways

P-Value

No of genes

LEC

  

Oxidative Phosphorylation

4.52E-17

29

Ubiquinone biosynthesis

8.04E-12

14

Purine metabolism

0.00166

18

Pyrimidine metabolism

0.0274

9

Limbus

  

Pentose Phosphate Pathway

0.0014

5

Oxidative Phosphorylation

0.00795

7

Valine, Leucine and Isoleucine Biosynthesis

0.00851

2

Alanine and aspartate metabolism

0.0151

3

Glycolysis/gluconeogenesis

0.047

4

Cornea

  

Oxidative Phosphorylation

3.48E-21

41

Ubiquinone Biosynthesis

2.14E-08

16

Purine metabolism

0.000118

30

Alanine and Aspartate metabolism

0.000869

9

Glutathione metabolism

0.00607

8

Glycolysis/gluconeogenesis

0.00855

12

Lysine biosynthesis

0.0402

2

Citrate cycle

0.042

4

Pyruvate metabolism

0.0451

8

Canonical Signaling Pathways

  

LEC

  

NRF2-mediated Oxidative Stress Response

2.29E-05

16

Nucleotide Excision Repair Pathway

3.17E-05

7

Protein Ubiquitination Pathway

2.06E-05

16

Estrogen Receptor Signaling

8.79E-03

8

Glucocorticoid Receptor Signaling

1.81E-02

13

Limbus

  

NRF2-mediated Oxidative Stress Response

2.81E-02

7

Regulation of actin based motility by Rho

4.51E-02

4

Cornea

  

NRF2 mediated Oxidative Stress Response

2.51E-04

21

Protein Ubiquitination Pathway

3.09E-07

26

Estrogen Receptor Signaling

3.67E-04

15

Antigen Presentation Pathway

1.29E-03

7

VDR/RXR Activation

6.31E-03

10

Glucocorticoid Receptor Signaling

3.05E-02

20

Nucleotide Excision repair

2.77E-04

8