Figure 1

The identified mosquito LRIM proteins can be classified into four distinct subfamilies. LRIM family members that match all the defining features are classified as Long LRIMs with 10 or more LRRs, and Short LRIMs with 6 or 7 LRRs. Those exhibiting the defining features but which are additionally predicted to contain a C-terminal transmembrane domain are classified as TM LRIMs, and those lacking only the coiled-coil domain are termed Coil-less LRIMs. The repeating LRR units form a horseshoe-like structure where the short beta-strands form a parallel beta sheet on the concave face of the arc and the linking helices or turns lie on the convex face.