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Figure 6 | BMC Genomics

Figure 6

From: Scoring of senescence signalling in multiple human tumour gene expression datasets, identification of a correlation between senescence score and drug toxicity in the NCI60 panel and a pro-inflammatory signature correlating with survival advantage in peritoneal mesothelioma

Figure 6

Supervised hierarchical clustering using the mSS signature highlights gene groups correlating with survival in peritoneal mesotheliomas. Clustering of mesothelioma samples is shown in (A). Group A tumours had higher expression of group 1 genes and lower expression of group 2 genes, corresponding to a potential pro-inflammatory phenotype. Gene groups are given in Table 3. (B-D) Kaplan-Meier survival analyses of tumour groups from mSS supervised hierarchical clustering. (B) Peritoneal mesotheliomas, (C) MPNST and (D) Liposarcoma. Only mesothelioma samples showed a significant association with survival improvement. P values shown in brackets are p-values after adjustment for age and sex. All survival analysis performed in SPSS (version 15).

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