Figure 6From: Scoring of senescence signalling in multiple human tumour gene expression datasets, identification of a correlation between senescence score and drug toxicity in the NCI60 panel and a pro-inflammatory signature correlating with survival advantage in peritoneal mesotheliomaSupervised hierarchical clustering using the mSS signature highlights gene groups correlating with survival in peritoneal mesotheliomas. Clustering of mesothelioma samples is shown in (A). Group A tumours had higher expression of group 1 genes and lower expression of group 2 genes, corresponding to a potential pro-inflammatory phenotype. Gene groups are given in Table 3. (B-D) Kaplan-Meier survival analyses of tumour groups from mSS supervised hierarchical clustering. (B) Peritoneal mesotheliomas, (C) MPNST and (D) Liposarcoma. Only mesothelioma samples showed a significant association with survival improvement. P values shown in brackets are p-values after adjustment for age and sex. All survival analysis performed in SPSS (version 15).Back to article page