A potential role for intragenic miRNAs on their hosts' interactome

BMC Genomics

Table 4 Conservation of miRNA-Host Pairs

Organism	miRNA-Host Pairs Predicted to Target own Host		miRNA-Host Pairs Not Predicted to Target own Host		p-Value
	Conserved	Total	Conserved	Total
Homo sapiens - Mus musculus	18 (35.2%)	51	41 (24.5%)	167	0.18
Homo sapiens - Canis familiaris	1 (2.12%)	47	0	142	0.56
Homo sapiens - Gallus gallus	5 (12.5%)	40	1 (0.71%)	139	0.001

The subset of intragenic miRNA host pairs where the miRNA is predicted to target its own host shows a tendency to be more conserved. However, statistical significance can only be shown for conservation between human and chicken (2-sample test for equality of proportions with continuity correction).

ISSN: 1471-2164