Figure 3

Examples of structural differences between annotated RefSeq orthologs in human and mouse. (A) Exalign structural alignment between ZMYND11 RefSeq transcripts NM_006624 (human) and NM_144516 (mouse); the four domains of the protein encoded by NM_006624, as identified by PFAM: from left to right a PHD domain, a bromodomain, a PWWP domain and a MYND finger domain; the three domains of the protein encoded by NM_144516 as identified by PFAM: a bromodomain, a PWWP domain and a MYND finger domain. The mouse isoform annotated in ASPicDB under the signature ID: a5923ed871:15 [39] has a structure identical to human NM_006624. (B) Exalign alignment between HTRA3 RefSeq transcripts NM_053044 (human) and NM_001042615 (mouse); the three PFAM domains annotated on the protein encoded by NM_053044: a Kazal-2 domain, a trypsin domain and a PDZ domain; the two domains of the protein encoded by NM_001042615 identified by PFAM: a Kazal-2 domain and a trypsin domain. The human ASPicDB isoform (signature ID: a37c4f0b80:7) has a structure identical to mouse NM_001042615. (C) Exalign alignment between RAB15 RefSeq transcripts NM_134050 (mouse) and NM_198686 (human); the protein encoded by NM_198686 presents a truncated RAS domain while the protein encoded by NM_134050 shows a complete RAS domain. The human ASPicDB isoform d47ccf3a53:7 has a structure identical to mouse NM_134050. Orthologous isoforms not included in the RefSeq database but supported by transcript evidences and collected in ASPicDB [13] as well as in other alternative splicing databases [38] are indicated in blue by their unique signature ID [39].