Examples of structural differences between annotated RefSeq orthologs in human and mouse. (A) Exalign structural alignment between ZMYND11 RefSeq transcripts NM_006624 (human) and NM_144516 (mouse); the four domains of the protein encoded by NM_006624, as identified by PFAM: from left to right a PHD domain, a bromodomain, a PWWP domain and a MYND finger domain; the three domains of the protein encoded by NM_144516 as identified by PFAM: a bromodomain, a PWWP domain and a MYND finger domain. The mouse isoform annotated in ASPicDB under the signature ID: a5923ed871:15  has a structure identical to human NM_006624. (B) Exalign alignment between HTRA3 RefSeq transcripts NM_053044 (human) and NM_001042615 (mouse); the three PFAM domains annotated on the protein encoded by NM_053044: a Kazal-2 domain, a trypsin domain and a PDZ domain; the two domains of the protein encoded by NM_001042615 identified by PFAM: a Kazal-2 domain and a trypsin domain. The human ASPicDB isoform (signature ID: a37c4f0b80:7) has a structure identical to mouse NM_001042615. (C) Exalign alignment between RAB15 RefSeq transcripts NM_134050 (mouse) and NM_198686 (human); the protein encoded by NM_198686 presents a truncated RAS domain while the protein encoded by NM_134050 shows a complete RAS domain. The human ASPicDB isoform d47ccf3a53:7 has a structure identical to mouse NM_134050. Orthologous isoforms not included in the RefSeq database but supported by transcript evidences and collected in ASPicDB  as well as in other alternative splicing databases  are indicated in blue by their unique signature ID .