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Figure 5 | BMC Genomics

Figure 5

From: Aberrant host immune response induced by highly virulent PRRSV identified by digital gene expression tag profiling

Figure 5

Induction of innate immune responses in pigs infected with H-PRRSV. PAMPs in H-PRRSV viral proteins and nucleic acids are recognized by PRRs that include TLRs (A), cell surface and cytoplasmic PRRs (B), Fc and other receptors (C). After binding to H-PRRSV viral PAMPs, PRRs initiate intracellular signaling cascades that activate transcription factors including IRFs (D) and STATs (F), which in turn induce the expression of IFN╬│ but not SPIIFNs (E), ISGs (G), pro-inflammatory cytokines and receptors (J), chemokines and receptors (K). Simultaneously, H-PRRSV infection activated complement proteins (I), selectin ligands, adhesion molecules and integrins (H). These recruit immune cells to sites of infection, resulting in severe inflammation and tissue damage. Figure 1H-K represent the heat maps of those DE genes selected. Genes shown in red were up-regulated and those shown in green were down-regulated in infected pigs relative to C pigs (See Additional file 2 for full gene names).

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