Figure 3

Stress-induced pathways in the PVN of the hypothalamus of DBA/2J (A) and C57BL/6 (B) mice. Using a pathway building program, connections between the group of genes regulated at 4 h and the group of genes regulated at 8 h after stress were determined, as well as connections within groups. Gene names identified on the microarray are circled, the direction of expression change is indicated by plus or minus signs. GNAi2: guanine nucleotide binding protein, alpha inhibiting 2; NFATc1: nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1; APP: amyloid beta (A4) precursor protein; HSPAIA: HSP70 heat Shock protein 70; ADCY2: adenyl cyclase 2;IL1F8: Interleukin 18; PAK2: p21 (CDKN1A) activated kinase 2); SPRY2: sprouty homolog 2 (Drosophila); NME1: expressed in non-metastatic cells 1 protein; GNAO1: guanine nucleotide binding protein, alpha; RGS2: regulator of G-protein signaling 2; TNF: tumor necrosis factor alpha; EGF: epidermal growth factor (beta-urogastrone); cAMP: cyclic AMP. Arrows indicate a positive, blunted lines a negative effect on expression, molecular synthesis or activity of the respective entity (e.g. protein, small molecule etc.).