Figure 2

The composite profiles on an average gene and its neighbors. Composite profiles on 7 linked genes according to the occupancy or change of histone modification of the target gene (the middle one) observed. The target genes were assigned to I of 3 groups according to their mean level of occupancy or change in translated or promoter regions (low, bottom 20%; middle, middle 60%; and high, top 20%). The ends of ORFs were fixed and each translated region and intergenic region was divided equally into 40 and 20 bins, respectively. The average occupancy or change of modification for each bin is plotted. (A) and (B) Composite profiles of no-antibody control data according to the data level in translated/promoter regions of the target gene. (C) and (D) Composite profiles of H3K9ac according to the H3K9ac level in translated/promoter regions of target gene. (E) and (F) Composite profiles of ΔH3K14ac according to the ΔH3K14ac level in translated/promoter regions of the target gene.