Strategy for RGP identification and classification in the Photorhabdus luminescens TT01 (Pl), Photorhabdus asymbiotica ATCC43949 (Pa), Xenorhabdus nematophila ATCC19061 (Xn) and Xenorhabdus bovienii SS-2004 (Xb) genomes. A. Schematic representation of the procedure used by RGPFinder to identify synteny ruptures in the core genome (http://www.genoscope.cns.fr/agc/mage; Roche et al., unpublished data). In the example shown, the reference genome, the P. luminescens TT01 (Pl) genome, is compared with a bacterial genome set, the Entero set, composed of the P. asymbiotica ATCC43949 (Pa), X. nematophila ATCC19061 (Xn), X. bovienii SS-2004 (Xb), Yersinia pestis CO92 (Yp), Salmonella enterica subsp. enterica Typhi CT18 (St), Erwinia carotovora subsp. atroseptica SCRI1043 (Eca) and E. coli K12 (Eco) genomes. A region of genomic plasticity (RGP) sensu lato is the sum of overlapping subregions missing from at least one of the genomes in the bacterial genome set. RGPs have a minimal size of 5 kb. B. Classification of the RGPs sensu lato as a function of the genetic features identified by RGPFinder and Prophinder http://aclame.ulb.ac.be/Tools/Prophinder/.