Skip to main content

Table 3 Comparison of gene expression in copy number neutral (CNN) genes with LOH and without LOH (normal) (N = 46 genes significantly differentially-expressed 2-fold or greater)*

From: Genome wide analysis of DNA copy number neutral loss of heterozygosity (CNNLOH) and its relation to gene expression in esophageal squamous cell carcinoma

Gene name

Cytoband

Probeset on U133A array

No. cases with LOH

No. cases without LOH

No. SNPs

Fold change CNN with LOH

Fold change CNN without LOH

T-test

P-value

Genes where expression level of CNN with LOH is less than CNN without LOH (N = 28 genes)

ADK

chr10q22|10q11-q24

204120_s_at

2

13

46

0.404

0.606

3.138

8.559E-03

ADK

chr10q22|10q11-q24

204119_s_at

2

13

46

0.411

0.619

3.195

7.278E-03

AIM1L

chr1p36.11

220289_s_at

2

15

6

0.093

0.201

3.548

4.812E-03

APOL6

chr22q12.3

219716_at

2

5

4

0.467

0.894

4.659

9.543E-03

ATP6V0E1

chr5q35.2

201171_at

2

12

5

0.375

0.669

3.234

9.843E-03

ATP6V0E1

chr5q35.2

200096_s_at

2

12

5

0.480

0.872

4.445

5.699E-03

BACH1

chr21q22.11

204194_at

2

12

9

0.498

0.738

3.970

2.098E-03

BTG2

chr1q32

201236_s_at

2

14

1

0.460

0.986

4.095

1.183E-03

CD2

chr1p13.1

205831_at

2

14

1

0.324

0.628

3.462

9.221E-03

CEACAM6

chr19q13.2

211657_at

2

13

3

0.007

0.100

4.779

7.023E-03

CRAT

chr9q34.1

209522_s_at

7

8

1

0.293

0.567

3.169

7.495E-03

CSDE1

chr1p22

202646_s_at

2

14

3

0.343

0.895

7.835

7.590E-05

CYP4F3

chr19p13.2

206515_at

2

13

136

0.065

0.307

3.329

5.631E-03

DIO2

chr14q24.2-q24.3

203699_s_at

2

11

4

0.072

0.127

3.565

6.175E-03

DIO2

chr14q24.2-q24.3

203700_s_at

2

11

4

0.168

0.280

3.697

3.752E-03

EIF4EBP2

chr10q21-q22

208770_s_at

2

14

1

0.452

0.657

6.300

2.692E-05

FAS

chr10q24.1

216252_x_at

2

13

8

0.412

0.648

3.058

9.883E-03

HERC6

chr4q22.1

219352_at

3

9

1

0.105

0.538

5.769

2.901E-04

ICAM3

chr19p13.3-p13.2

204949_at

2

13

2

0.356

0.602

3.478

4.342E-03

IL1RN

chr2q14.2

212659_s_at

2

12

13

0.073

0.142

3.256

7.793E-03

NADSYN1

chr11q13.4

218840_s_at

2

8

10

0.448

0.649

3.399

9.384E-03

NHP2

chr5q35.3

216583_x_at

2

10

1

0.497

0.774

4.091

2.584E-03

PDCD4

chr10q24

202730_s_at

2

12

4

0.212

0.363

4.483

9.256E-04

PPP1R13L

chr19q13.32

218849_s_at

3

13

1

0.190

0.487

5.016

5.018E-04

RIPK4

chr21q22.3

221215_s_at

5

10

7

0.217

0.454

3.614

3.658E-03

SKAP2

chr7p21-p15

216899_s_at

2

10

12

0.293

0.615

4.165

1.973E-03

SKAP2

chr7p21-p15

204361_s_at

2

10

43

0.359

0.665

4.384

1.591E-03

SLC6A1

chr3p25-p24

205152_at

2

8

6

0.158

0.438

5.044

2.481E-03

STK39

chr2q24.3

202786_at

2

12

86

0.151

0.290

3.363

6.327E-03

SYNPO2L

chr10q22.2

219804_at

3

13

1

0.063

0.345

6.925

8.703E-06

TGM5

chr15q15.2

207911_s_at

2

13

8

0.382

0.517

3.496

4.389E-03

ZNF91

chr19p13.1-p12

206059_at

2

10

5

0.026

0.551

9.054

6.430E-04

Genes where expression level of CNN with LOH is greater than CNN without LOH (N = 18 genes)

ACVR1

chr2q23-q24

203935_at

2

12

13

3.480

1.751

-4.533

7.869E-04

ASPN

chr9q22

219087_at

5

10

2

10.594

2.679

-3.792

2.667E-03

BUB1

chr2q14

209642_at

2

12

2

8.571

4.010

-3.922

2.170E-03

CALU

chr7q32.1

200757_s_at

2

12

7

3.467

1.830

-4.612

7.505E-04

CALU

chr7q32.1

200755_s_at

2

12

7

3.899

1.981

-3.903

2.269E-03

CAMSAP1L1

chr1q32.1

212765_at

2

13

3

3.000

1.357

-6.288

1.629E-03

CENPF

chr1q32-q41

209172_s_at

2

14

10

5.481

2.643

-5.909

3.926E-05

CSNK1E

chr22q13.1

202332_at

2

3

4

2.933

1.157

-7.434

9.278E-03

FAM13A

chr4q22.1

202973_x_at

3

10

14

2.756

1.149

-3.508

6.115E-03

FHL2

chr2q12-q14

202949_s_at

2

14

15

3.159

1.244

-4.697

4.097E-04

GSR

chr8p21.1

205770_at

3

10

8

2.505

1.222

-3.701

4.824E-03

ITGA6

chr2q31.1

201656_at

2

11

21

4.038

2.400

-3.519

4.820E-03

KIF14

chr1q32.1

206364_at

2

13

6

11.027

3.578

-8.257

2.071E-06

NCAPH

chr2q11.2

212949_at

2

11

2

3.643

1.943

-5.087

4.450E-04

NRP2

chr2q33.3

214632_at

3

11

29

2.161

1.257

-3.500

9.276E-03

RBM28

chr7q32.1

218593_at

2

11

9

2.210

1.555

-3.976

2.370E-03

SMAD5

chr5q31

205187_at

2

12

3

2.208

0.829

-10.692

3.171E-07

STEAP3

chr2q14.2

218424_s_at

2

14

12

2.707

1.207

-6.922

9.985E-06

TGS1

chr8q11

219231_at

2

8

1

2.533

1.656

-3.495

8.601E-03

  1. *Sorted alphabetically by gene name