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Table 2 Summary of differentially expressed genes in the livers of female Sprague-Dawley rats following p.o. exposure to TCDD, PCB126 and PCB153 for 13 and 52 weeks

From: Toxicogenomic analysis of exposure to TCDD, PCB126 and PCB153: identification of genomic biomarkers of exposure to AhR ligands

13 Week Subchronic Exposure Experiment  
Exposure Group Number of Differentially Expressed Genes
100 ng/kg/day TCDD 103 (18)
1000 ng/kg/day PCB126 371 (164)
1000 μg/kg/day PCB153 39 (0)
52 Week Chronic Exposure Experiment  
Exposure Group Number of Differentially Expressed Genes
100 ng/kg/day TCDD 299 (22)
30 ng/kg/day PCB126 52 (1)
300 ng/kg/day PCB126 128 (15)
1000 ng/kg/day PCB126 216 (171)
1000 μg/kg/day PCB153 47 (1)
  1. Shown are the total number of probe sets exhibiting a ≥ 2-fold change in expression and a p-value < 0.05 following the specified treatments. In parenthesis are probe sets that are still significant following Benjamini-Hochberg false discovery rate correction.