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Table 3 Relative fold change in 16 genes differentially expressed in livers of female Sprague-Dawley rats following 52 weeks of chronic p.o. exposure to 30 ng, 300 ng and 1000 ng/kg/day PCB126

From: Toxicogenomic analysis of exposure to TCDD, PCB126 and PCB153: identification of genomic biomarkers of exposure to AhR ligands

    PCB126 dose (ng/kg/d)
Transcript ID Gene Symbol Gene Name 30 300 1000
NM_012540 Cyp1a1a Cytochrome P450, family 1, subfamily a, polypeptide 1 499* 1263* 1551*
NM_012940 Cyp1b1a Cytochrome P450, family 1, subfamily b, polypeptide 1 18 866* 2091*
NM_173339 Ceacam10b CEA-related cell adhesion molecule 10 17 660* 976*
NM_031530 Ccl2 Chemokine (C-C motif) ligand 2 5 11 31*
NM_001039691///NM_057105 Ugt1a6a UDP glycosyltransferase 1 family, polypeptide A6 3 11* 16*
NM_130407 Ugt1a7a UDP glycosyltransferase 1 family, polypeptide A7 3 23* 40*
NM_017127 Chka Choline kinase alpha 2 7* 6*
NM_012656 Sparc Secreted acidic cysteine rich glycoprotein 2 2 4*
NM_031569///NM_057098///XM_001055907///XM_345486 Oprl1///Tcea2 Opioid receptor-like 1///Transcription elongation factor A (SII), 2 2 4 4*
NM_024127 Gadd45a Growth arrest and DNA-damage-inducible 45 alpha 2 4 4*
NM_012600 Me1 Malic enzyme 1 2 2* 4*
NM_001037979 Adipor2b Adiponectin receptor 2 -3 -2 -6*
NM_012672 Thrb Thyroid hormone receptor beta -3 -3 -3*
NM_032071 Synj2 Synaptojanin 2 -3 -3 -4*
XM_001071608///XM_213849 Nfix Nuclear factor I/X -3 -3 -5*
NM_012988 Nfia Nuclear factor I/A -4 -4 -3*
  1. a Statistically different (p-value = 0.05) between doses using ANOVA with Tukey post-hoc test; b Statistically different between 300 ng and 1000 ng doses only; * Genes with p-value < 0.05 following Benjamini-Hochberg FDR correction.