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Table 4 Relative fold change in genes differentially expressed in livers of female Sprague-Dawley rats following 13 weeks and 52 weeks of p.o. exposure to 1000 ng/kg/day PCB126 and 100 ng/kg/day TCDD, and 24 h post-exposure to 5 μg/kg TCDD, p.o.

From: Toxicogenomic analysis of exposure to TCDD, PCB126 and PCB153: identification of genomic biomarkers of exposure to AhR ligands

Gene Symbol Gene Name 13 wk PCB126a 13 wk TCDDa 52 wk PCB126a 52 wk TCDDa 24 h TCDDb DRE site in Ratc DRE site in Humanc
Cyp1a1 Cytochrome P450, family 1, subfamily a, polypeptide 1 1140* 1026* 1551* 1277* 127881** YES (8) YES (11)
Cyp1b1 Cytochrome P450, family 1, subfamily b, polypeptide 1 519* 743* 2091* 1288* 121d** YES (9) YES (7)
Ceacam10 CEA-related cell adhesion molecule 10 369* 620* 976* 973* 8.5** NO N/P
Cox8h Cytochrome c oxidase subunit VIII-H (heart/muscle) 66* 312* 24* 27* N/D NO N/A
Nqo1 NAD(P)H dehydrogenase, quinone 1 21* 20 9* 8* 37.0** YES (7) YES (2)
Ugt1a7 UDP glycosyltransferase 1 family, polypeptide A7 14* 85* 40* 33* 24.5** YES (4) YES (2)
Ugt1a6 UDP glycosyltransferase 1 family, polypeptide A6 11* 56* 16* 12* 383.6** YES (6) YES (2)
Cyp1a2 Cytochrome P450, family 1, subfamily a, polypeptide 2 7* 3* 2* 2 38.5** NO YES (3)
Enpp2 Ectonucleotide pyrophosphatase/phosphodiesterase 2 6* 6* 5* 4 2.6** YES (1) NO
Exoc3 Exocyst complex component 3 6* 32* 21* 23* 8.1** NO YES (7)
Aldh3a1 Aldehyde dehydrogenase family 3, member A1 5* 57* 1493* 1156* 10.2** YES (2) YES (5)
Me1 Malic enzyme 1 4* 3 4* 3 2.4** YES (2) YES (2)
Trib3 Tribbles homolog 3 (Drosophila) 2* 8* 13* 16 2.2** YES (1) YES (3)
Tsc22d1 TSC22 domain family, member 1 -2 -2 -6* -4 1.5 YES (4) YES (2)
Gls2 Glutaminase 2 (liver, mitochondrial) -2* -3 -6* -4 -2.5** YES (2) YES (3)
Zfp354a Zinc finger protein 354A -2 -2 -8* -5 -5.3 YES (1) YES (1)
Alas1 Aminolevulinic acid synthase 1 -2* -2 -3 -3 -1.6 N/A YES (2)
Phyh2 Phytanoyl-CoA 2-hydroxylase 2 -2 -4 -3* -3 -1.6 YES (1) YES (1)
Ca2 Carbonic anhydrase 2 -3 -8* -6* -3 -1.9d NO YES (4)
Sfxn1 Sideroflexin 1 -3* -3* -3* -2 -2.9 NO YES (2)
Mtmr7 Myotubularin related protein 7 -3* -3 -5* -5 -3.0** N/A YES (2)
Pik3c2g Phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide -3 -2 -3* -3 -1.5 NO NO
Acsm2 Acyl-CoA synthetase medium-chain family member 2 -3 -26 -12* -14 -3.9 YES (2) N/P
Slc29a1 Solute carrier family 29 (nucleoside transporters), member 1 -3* -3 -3* -2* -2.1 YES (2) YES (1)
Cadps Ca2+-dependent secretion activator -3 -3 -3 -3 -2.6** YES (1) YES (5)
Hal Histidine ammonia lyase -3 -2 -17* -10 -1.3 YES (2) NO
Cyp3a13 Cytochrome P450, family 3, subfamily a, polypeptide 13 -3 -139* -610* -606* -5.6d** NO N/P
Ptprd Protein tyrosine phosphatase, receptor type, D -3* -2 -3 -2 -1.9 YES (4) YES (2)
Ces3 Carboxylesterase 3 -3* -9 -9* -6 -2.8d NO YES (2)
Mgst3 Microsomal glutathione S-transferase 3 -3 -3 -4* -4 -3.4** YES (7) YES (4)
Serpina7 Serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antipeptidase, antitrypsin), member 7 -3 -15 -21* -16 -3.3d NO NO
Nr0b2 Nuclear receptor subfamily 0, group B, member 2 -3* -2 -3* -2 -6.4** NO YES (2)
Aspg Asparaginase homolog (S. cerevisiae) -4* -10 -41* -28 -4.1** YES (8) N/P
Il33 Il33 interleukin 33 -4* -3 -3* -3 -2.1** NO N/P
Ptprn Protein tyrosine phosphatase, receptor type, N -4 -3 -4* -3 -1 YES (2) YES (1)
Srd5a1 Steroid 5 alpha-reductase 1 -4 -6 -14* -11 -2.0d** YES (1) YES (8)
Enpp3 Ectonucleotide pyrophosphatase/phosphodiesterase 3 -4* -4* -5* -4 -2.3** NO NO
Pdp2 Pyruvate dehydrogenase phosphatase isoenzyme 2 -4 -3 -9* -3 -1.8 YES (1) YES (3)
Ugt1a1 UDP glycosyltransferase 1 family, polypeptide A1 -5* -3 -3* -3 -1.3 YES (4) YES (4)
Slc13a3 Solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 -5 -7 -4* -5 -3.3d** YES (3) YES (1)
Resp18 Regulated endocrine-specific protein 18 -7 -6 -15* -34 -5.7** NO N/A
  1. Shown are genes for which expression from microarray analysis significantly differed (p < 0.05 as determined by the student t-test), by at least 2-fold, compared to the control group. a Fold changes in hepatic gene expression from microarray analysis; b Fold changes in hepatic gene expression from qPCR at 24 h post-exposure to TCDD; c DREs identified in genomic DNA sequences spanning 5000 bp above and 1000 bp below the transcriptional start site. The number in parenthesis indicates the number of DREs present; d Values from Ovando et al. 2006; *Genes with p-value < 0.05 following Benjamini-Hochberg FDR correction; **Statistically different (P ≤ 0.05) between control and treated animals (n = 3) for qPCR; N/P - Gene not present in human genome; N/D - Gene expression could not be evaluated for that treatment; N/A - Not available in the UCSC genome bioinformatics database.