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Figure 1 | BMC Genomics

Figure 1

From: Is human blood a good surrogate for brain tissue in transcriptional studies?

Figure 1

Studying the brain module preservation in human blood. The row bars correspond to brain co-expression modules found by Oldham et al. (2008). Modules are labeled by a color. For each module color, there are two horizontal bars which correspond to the module preservation Z statistics in the Dutch blood data and the SAFHS blood data, respectively. The two red vertical lines correspond to thresholds of moderate preservation (5) and strong preservation (10). Panel (a) shows that only three (yellow, green, and blue) out of 19 cortex modules showed strong preservation in both blood data sets. Panel (b) shows that only one (yellow) out of 23 caudate nucleus modules was strongly preserved in both blood data sets. Panel (c) shows that only one (blue) out of 22 cerebellum modules was strongly preserved in both blood data sets. In summary, only five modules from Oldham et al. (2008) show strong evidence of preservation in human blood.

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