Skip to main content
Figure 4 | BMC Genomics

Figure 4

From: Is human blood a good surrogate for brain tissue in transcriptional studies?

Figure 4

Relationships between the module membership measures of the three preserved cortex modules. Relationships between the module membership of blue/CTX, yellow/CTX and green/CTX modules in blood (a-c) and in the original cortex brain samples (d-f). Panel (a) shows that the correlation between MMyellow and MMblue equaled 1 in the blood data, which reflects the fact that these modules were indistinguishable in blood. In contrast, panel (d) shows that correlation between MMyellow and MMblue equaled 0.62 in cortex. Figure (b-c) shows that MMgreen had a correlation close to -1 with MMyellow (b) and MMblue (c) in blood. We report both uncorrected correlation test p-values and Bonferroni corrected p-value (inside of brackets). Given the very high correlations between MMgreen, MMyellow, and MMblue in blood, we combined the three measures in an overall module membership measure referred to as MM.combined.Blood. Analogously, we combined the three MM measures for the cortex network (referred to as MM.combined.CTX).

Back to article page