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Table 2 Significance scores for structure predictions for selected P-DUDES domains

From: A widespread peroxiredoxin-like domain present in tumor suppression- and progression-implicated proteins

PSI-Blast hits in the PDB database

domain

First PDB hit (PDB ID)

iteration

E-value

CCDC80-II

2h01|A, Plasmodium yoelii Thioredoxin Peroxidase I

4

4e-05

CCDC80-I

3drn|A, Sulfolobus sulfataricus Bcp1

6

8e-08

CCDC80-III

2h01|A

3

2e-04

SRPX

3drn|A

4

4e-04

SRPX2

3drn|A

3

0.004

FFAS hits in the PDB database. Z-score below -9.5 means significant similarity (less than 3% of false positives)[27]

domain

First PDB hit (PDB ID)

Sequence identity

Z-score

CCDC80-II

3drn_A

12

-35.5

CCDC80-I

3drn_A

11

-18.6

CCDC80-III

3drn_A

9

-40.1

SRPX

3drn_A

10

-30.3

SRPX2

3drn_A

15

-35.7

HHpred hits in the PDB database

domain

First PDB hit (PDB ID)

E-value

 

CCDC80-II

3drn_A

0.00093

 

CCDC80-I

3drn_A

0.00081

 

CCDC80-III

2h01_A

1.1E-20

 

SRPX

3drn_A

0.0011

 

SRPX2

3drn_A

0.00018

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