Figure 4
From: Conserved and variable correlated mutations in the plant MADS protein network
Conserved intermolecular correlated mutation. (A) Illustration of conserved correlated mutation concept: a correlated mutation is observed at homologous positions in two sequence alignments for two different MADS-domain protein subfamilies (or for two different pairs of interacting MADS domain protein subfamilies). (B) Two chains of MADS domain protein dimer (structure with PDB id 1n6j) are shown in blue and red. Spacefill indicates residues 47 and 66, which are located close to each other and which are detected as a correlated mutation pair both in the interacting pair AGL6-SOC1 and SEP1-SOC1.