Table 4 Protein Models: AnEnπ and enzyme classifications, and model quality.
AnEnÎ | Enzyme Classes | Quality Models | TOTAL | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Â | Â | 1 | 2 | 3 | 4 | 5 | 6 | 7 | Â |
1. Homologous | Oxidorreductases | 5 | 16 | - | 25 | 8 | 4 | 1 | 59 (trypanothione-disulfide reductase) |
| Â | Transferases | 7 | 17 | 3 | 41 | 12b | 15 | 9 | 104 (protein kinases, polymerases) |
| Â | Hydrolases | - | 9 | 5 | 38 | 17 | 14 | 10 | 93 (trans-sialidase, endopeptidases) |
| Â | Lyases | - | 12 | 1 | 1 | 4 | 2 | - | 20 (hydratases, endonucleases) |
| Â | Isomerases | - | 1 | 3 | 8 | 1 | 7 | 2 | 22 (peptidylprolyl isomerase) |
| Â | Ligases | - | 8 | 1 | 14 | - | 5 | 5 | 33 (glutathione synthase, ubiquitins) |
2. Analogous | Oxidorreductases | - | - | - | 1 | 1 | - | - | 2 (dehydrogenases) |
| Â | Hydrolases | - | - | - | 1 | - | - | - | 1 (phosphatases) |
3. Specific ofT. cruzi | Oxidorreductases | 1 | - | 1 | - | - | - | - | 2 (trypanothione-disulfide reductase) |
| Â | Transferases | - | - | - | 2 | - | - | - | 2 (protein kinases, polymerases) |
| Â | Hydrolases | - | - | 2 | 23 | 1 | 4 | 4 | 34 (cruzipain, leishmanolisin) |
4. Undetermined a | Hydrolases | - | - | - | 22 | - | - | - | 22 (leishmanolisin) |
| Â | Lyases | - | - | - | - | - | - | 3 | 3 (hydratases, endonucleases) |
TOTAL | Â | 13 | 63 | 16 | 176 | 44 | 51 | 34 | 397 |