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Table 1 Changes in gene expression in BMDCs in response to treatment with [BF/S+L/Ep]

From: Stimulatory effect of Echinacea purpurea extract on the trafficking activity of mouse dendritic cells: revealed by genomic and proteomic analyses

 

Expression change relative to DMSO alone

Up-regulated genes

Down-regulated genes

Total number of regulated genes

Percentage of all genes (%)

At 4 h:

     

Total genes

Significant a

513

472

985

2.90

 

≥ 1.5

104

94

198

0.58

 

≥ 2 b

19

10

29

0.09

 

≥ 3

6

5

11

0.03

 

≥ 4

3

2

5

0.01

Immune-related

Significant a

89

83

172

0.51

 

≥ 1.5

16

14

30

0.09

 

≥ 2 c

4

0

4

0.01

 

≥ 3

2

0

2

0.01

 

≥ 4

0

0

0

0

Non-immune-

related

≥ 2 b-c

15

10

25

0.07

At 12 h:

     

Total Genes

Significant a

605

736

1341

3.94

 

≥ 1.5

128

132

260

0.76

 

≥ 2 d

21

18

39

0.11

 

≥ 3

6

5

11

0.03

 

≥ 4

3

3

6

0.02

Immune-related

Significant a

144

120

264

0.78

 

≥ 1.5

27

19

46

0.14

 

≥ 2 e

2

0

2

0.01

 

≥ 3

1

0

1

0

 

≥ 4

1

0

1

0

Non-immune-

related

≥ 2 d-e

19

18

37

0.11

  1. a Differentially expressed genes that are significant in [BF/S+L/Ep] vs. [DMSO] (control). Values of p ≤ 0.05 are considered to be significant. All relative differences greater than 1.5 are significant.
  2. b Up-regulated genes with at least a 2-fold change in the level of RNA transcript expression after 4 h treatment
  3. c Up-regulated immune-related genes with at least a 2-fold change after 4 h treatment
  4. d Down-regulated genes with at least a 2-fold change in the level of RNA transcript expression after 4 h treatment
  5. e Down-regulated immune-related genes with at least a 2-fold change after 12 h treatment