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Table 1 Changes in gene expression in BMDCs in response to treatment with [BF/S+L/Ep]

From: Stimulatory effect of Echinacea purpurea extract on the trafficking activity of mouse dendritic cells: revealed by genomic and proteomic analyses

  Expression change relative to DMSO alone Up-regulated genes Down-regulated genes Total number of regulated genes Percentage of all genes (%)
At 4 h:      
Total genes Significant a 513 472 985 2.90
  ≥ 1.5 104 94 198 0.58
  ≥ 2 b 19 10 29 0.09
  ≥ 3 6 5 11 0.03
  ≥ 4 3 2 5 0.01
Immune-related Significant a 89 83 172 0.51
  ≥ 1.5 16 14 30 0.09
  ≥ 2 c 4 0 4 0.01
  ≥ 3 2 0 2 0.01
  ≥ 4 0 0 0 0
Non-immune-
related
≥ 2 b-c 15 10 25 0.07
At 12 h:      
Total Genes Significant a 605 736 1341 3.94
  ≥ 1.5 128 132 260 0.76
  ≥ 2 d 21 18 39 0.11
  ≥ 3 6 5 11 0.03
  ≥ 4 3 3 6 0.02
Immune-related Significant a 144 120 264 0.78
  ≥ 1.5 27 19 46 0.14
  ≥ 2 e 2 0 2 0.01
  ≥ 3 1 0 1 0
  ≥ 4 1 0 1 0
Non-immune-
related
≥ 2 d-e 19 18 37 0.11
  1. a Differentially expressed genes that are significant in [BF/S+L/Ep] vs. [DMSO] (control). Values of p ≤ 0.05 are considered to be significant. All relative differences greater than 1.5 are significant.
  2. b Up-regulated genes with at least a 2-fold change in the level of RNA transcript expression after 4 h treatment
  3. c Up-regulated immune-related genes with at least a 2-fold change after 4 h treatment
  4. d Down-regulated genes with at least a 2-fold change in the level of RNA transcript expression after 4 h treatment
  5. e Down-regulated immune-related genes with at least a 2-fold change after 12 h treatment