|
Genes
|
Tag raw counts
|
Hand DII-V vs. Hand DI
|
Hand DII-V vs. Foot
|
Hand DI vs. Foot
|
|---|
| |
Hand DII-V
|
Hand DI
|
Foot
|
log2(Fold_change) normalized
|
p-value
|
log2(Fold_change) normalized
|
p-value
|
log2(Fold_change) normalized
|
p-value
|
|---|
|
Marker genes
| | | | | | |
|
Tbx5
|
175
|
134
|
6*
|
0.326
|
0.048
|
5.6385
|
1.04E-57
|
5.3125
|
1.81E-45
|
|
Pitx1
|
6
|
9
|
354*
|
-0.6441
|
0.3921
|
-5.1104
|
4.08E-67
|
-4.4663
|
3.04E-63
|
|
Meis2
b
|
73*
|
12
|
18
|
2.5457
|
1.13E-11
|
2.7922
|
5.00E-17
|
0.2465
|
0.6365
|
|
Hoxd10
b
|
61*
|
3
|
10
|
4.2866
|
1.09E-14
|
3.3811
|
5.17E-17
|
-0.9056
|
0.289
|
|
Krt17
ab
|
68*
|
267
|
455
|
-2.3284
|
2.28E-40
|
-1.9474
|
4.40E-38
|
0.381
|
0.0003
|
|
Elongated digits
| | | | | | |
|
Tbx3
b
|
118*
|
21
|
39
|
2.4312
|
4.16E-17
|
2.3695
|
2.10E-22
|
-0.0617
|
0.8689
|
|
Tbx15
b
|
171*
|
41
|
89
|
2.0011
|
2.79E-19
|
1.7144
|
2.10E-21
|
-0.2868
|
0.2648
|
|
Bmp3
b
|
19*
|
2
|
5
|
3.1888
|
1.04E-04
|
2.6983
|
2.64E-05
|
-0.4905
|
0.6626
|
|
Rgmb
b
|
727*
|
133
|
289
|
2.3914
|
5.76E-95
|
2.1031
|
8.28E-112
|
-0.2882
|
0.0435
|
|
Smad1
|
264*
|
122
|
250
|
1.0545
|
4.34E-12
|
0.8509
|
1.01E-11
|
-0.2036
|
0.1782
|
|
Smad4
|
412*
|
244
|
351
|
0.6966
|
1.19E-09
|
1.0034
|
1.60E-22
|
0.3068
|
0.0086
|
|
Nog
a
|
5**
|
17
|
44
|
-2.1207
|
1.53E-03
|
-2.3427
|
6.61E-06
|
-0.2219
|
0.5543
|
|
Hoxd8
|
19*
|
1
|
4
|
4.1888
|
1.81E-05
|
3.0202
|
8.64E-06
|
-1.1686
|
0.4084
|
|
Hoxd9
|
45*
|
10
|
13
|
2.1108
|
1.88E-06
|
2.5637
|
3.17E-10
|
0.4529
|
0.4442
|
|
Satb1
|
397*
|
117
|
286
|
1.7035
|
1.48E-34
|
1.2454
|
3.85E-30
|
-0.4581
|
0.0019
|
|
Hoxa1
b
|
61*
|
14
|
12
|
2.0642
|
4.50E-08
|
3.118
|
5.91E-16
|
1.0538
|
0.0577
|
|
Twist1
b
|
2521*
|
809
|
1767
|
1.5806
|
7.26E-189
|
1.285
|
4.31E-191
|
-0.2957
|
3.08E-07
|
|
Tmeff2
b
|
95*
|
22
|
50
|
2.0513
|
1.06E-11
|
1.6983
|
2.01E-12
|
-0.353
|
0.3091
|
|
Enpp2
b
|
27*
|
0
|
6
|
5.6957
|
8.71E-08
|
2.9422
|
1.64E-07
|
-2.7535
|
0.0698
|
|
Thumb &Foot
| | | | | | |
|
Tbx4
ab
|
20*
|
102
|
390
|
-2.7057
|
3.65E-19
|
-3.4906
|
2.48E-60
|
-0.7849
|
1.61E-08
|
|
Pitx2
|
21*
|
66
|
127
|
-1.7112
|
3.08E-07
|
-1.8241
|
6.16E-11
|
-0.1129
|
0.589
|
|
Acta1
ab
|
412*
|
1463
|
4918
|
-2.1834
|
1.81E-197
|
-2.7825
|
0
|
-0.5991
|
9.29E-57
|
|
Tnnc2
b
|
115*
|
534
|
1544
|
-2.2744
|
5.62E-69
|
-2.9747
|
6.36E-204
|
-0.7003
|
4.41E-26
|
|
Atp2a1
|
17*
|
103
|
223
|
-2.6582
|
3.49E-17
|
-2.9412
|
1.12E-30
|
-0.283
|
0.0813
|
|
Hrc
|
9*
|
40
|
67
|
-2.2112
|
2.34E-06
|
-2.1239
|
1.52E-07
|
0.0873
|
0.7535
|
|
Myoz1
|
8*
|
34
|
58
|
-2.1466
|
1.93E-05
|
-2.0857
|
1.37E-06
|
0.0609
|
0.8391
|
- a, homologs of mouse genes, all others are the homologs of human genes; b, genes expression patterns validated by RT-qPCR; * indicates gene expression in the library is significantly higher or lower than in other two libraries (*, p < 0.001; **, p < 0.01).
