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Table 4 Top five canonical pathways associated with each gene cluster following infestation with P. ovis

From: Transcriptomic analysis of the temporal host response to skin infestation with the ectoparasitic mite Psoroptes ovis

Temporal cluster* Canonical Pathway p-valueA
Cluster 1 p38 MAPK signalling 2.9E -05
  IL12 signalling and production in macrophages 5.4E-05
  IL10 signalling 6.9E-05
  Aryl hydrocarbon receptor signalling 1.3E-04
  PPAR signalling 2.9E-04
Cluster 2 IL10 signalling 1.2E -10
  Production of nitric oxide and reactive oxygen species in macrophages 1.0E-09
  Dendritic cell maturation 1.8E-09
  TREM1 signalling 1.8E-09
  NF-kB signalling 6.7E-09
Cluster 3 T helper cell differentiation 6.4E -08
  IL10 signalling 3.7E-06
  NF-kB signalling 1.6E-05
  Acute phase response signalling 6.1E-05
  TREM1 signalling 2.4E-04
Cluster 4 Interferon signalling 1.3E -05
  Leukocyte extravasation signalling 2.9E-05
  Antigen presentation pathway 3.9E-05
  T helper cell differentiation 1.7E-04
  CD28 signalling in T helper cells 1.9E-04
Cluster 6 Complement system 5.3E -12
  Role of pattern recognition receptors in recognition of bacteria and viruses 2.9E-06
  Acute phase response signalling 8.7E-05
  Role of macrophages, fibroblasts and endothelial cells in RA# 1.0E-03
  Wnt/beta-catenin signalling 2.3E-02
Cluster 7 Aryl hydrocarbon receptor signalling 3.5E -03
  Antiproliferative role of somatostatin receptor 2 7.1E-03
  CCR5 signalling in macrophages 3.8E-02
  Integrin signalling 5.8E-02
  IL1 signalling 7.7E-02
Cluster 8 Tight junction signalling 2.4E -03
  BMP signalling pathway 2.3E-02
  TGF beta signalling 2.8E-02
  IL6 signalling 3.8E-02
  Wnt/beta-catenin signalling 5.1E-02
  1. Key - *Cluster 5 contained too few genes for effective analysis of canonical pathways. #Rheumatoid arthritis. Ap-value calculated using Fisher's exact test determining the probability that association between genes in the data set and canonical pathway is due to chance alone