Table 4 Top five canonical pathways associated with each gene cluster following infestation with P. ovis

Cluster 1

p38 MAPK signalling

2.9E ^-05

IL12 signalling and production in macrophages

5.4E^-05

IL10 signalling

6.9E^-05

Aryl hydrocarbon receptor signalling

1.3E^-04

PPAR signalling

2.9E^-04

Cluster 2

IL10 signalling

1.2E ^-10

Production of nitric oxide and reactive oxygen species in macrophages

1.0E^-09

Dendritic cell maturation

1.8E^-09

TREM1 signalling

1.8E^-09

NF-kB signalling

6.7E^-09

Cluster 3

T helper cell differentiation

6.4E ^-08

IL10 signalling

3.7E^-06

NF-kB signalling

1.6E^-05

Acute phase response signalling

6.1E^-05

TREM1 signalling

2.4E^-04

Cluster 4

Interferon signalling

1.3E ^-05

Leukocyte extravasation signalling

2.9E^-05

Antigen presentation pathway

3.9E^-05

T helper cell differentiation

1.7E^-04

CD28 signalling in T helper cells

1.9E^-04

Cluster 6

Complement system

5.3E ^-12

Role of pattern recognition receptors in recognition of bacteria and viruses

2.9E^-06

Acute phase response signalling

8.7E^-05

Role of macrophages, fibroblasts and endothelial cells in RA^#

1.0E^-03

Wnt/beta-catenin signalling

2.3E^-02

Cluster 7

Aryl hydrocarbon receptor signalling

3.5E ^-03

Antiproliferative role of somatostatin receptor 2

7.1E^-03

CCR5 signalling in macrophages

3.8E^-02

Integrin signalling

5.8E^-02

IL1 signalling

7.7E^-02

Cluster 8

Tight junction signalling

2.4E ^-03

BMP signalling pathway

2.3E^-02

TGF beta signalling

2.8E^-02

IL6 signalling

3.8E^-02

Wnt/beta-catenin signalling

5.1E^-02