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Figure 1 | BMC Genomics

Figure 1

From: The human G93A-SOD1 mutation in a pre-symptomatic rat model of amyotrophic lateral sclerosis increases the vulnerability to a mild spinal cord compression

Figure 1

Temporal pattern of recovery of locomotor functions after mild compression SCI in the G93A-SOD1 rats and in the WT littermates. WT animals show a marked functional recovery between 1 and 2 days, followed by a steady locomotor improvement for the remaining period of observation. WT rats display an improved motor function compared to G93A-SOD1 rats from day 2 to day 7 of the post-injury experimental period (the difference between the WT and G93A-SOD1 locomotor functions is statistically significant only from the day 3, * P < 0.05), whereas G93A-SOD1 rats only appeared to perform slightly better, but non-significantly than the WT littermates at 4 hours and at 1 day post-injury. BBB scoring prior to injury of the G93A-SOD1 and the WT rats showed no locomotor dysfunction and no differences in BBB functional scores between the two genetic types (BBB score >21; normal locomotor functions). Error bars represent SEM. N: 5 animals per group were used.

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BMC Genomics

ISSN: 1471-2164

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