Figure 2

Number of differentially regulated genes at the site of compression spinal cord injury in the G93A-SOD1 rats and in the WT littermates. A. Graph displaying the total number of differentially regulated genes in the 10 week old WT and G93A-SOD1 spinal cord samples at the site of compression SCI. The largest difference in the number of differentially expressed gene candidates between the WT and the G93A-SOD1 spinal cord tissues is seen at the 7-day post-injury time point. B. Break-down of up-regulated versus down-regulated genes in the WT and G93A-SOD1 spinal cords at different time points from compression injury. The most remarkable difference between the two genetic types is the down-regulation of 135 genes in WT injured spinal cord tissue at 7 days post-injury, whilst G93A-SOD1 injured tissue down-regulate only 10 genes. Control: naïve and genetically-matched spinal cord samples (from 10 week old pre-symptomatic rats) were used as reference tissues in the differential gene expression analysis. Five animals per a group were used.