Figure 5

High throughput GoMiner ontological analysis of the differentially regulated genes in WT and G93A-SOD1 spinal cord at 30 minutes and 4 hours after laminectomy. The heat chart displays headings containing clusters of functionally related Gene ontology (GO) categories, computed using High Throughput GoMiner. Those gene categories found to be up-regulated in WT and G93A-SOD1 spinal cord tissue after laminectomy compared to naive and genetically matched spinal cord tissues are displayed in Figure 5A, whilst the gene categories which become down-regulated are reported in Figure 5B. At 4 hours from laminectomy, a large number of gene categories are over-expressed only in G93A-SOD1 spinal cord. At the 30 minutes time point, WT spinal cord gene expression differs from G93A-SOD1 tissue for the down-regulation of a number of cytoskeletal gene categories. 10 week old genetically age-matched spinal cord tissues were used as reference. Other: categories which include genes involved in the regulation of the action potential, of the DNA damage response and of signal transduction.