Figure 1

Data analysis pipeline to identify networks of genes associated with t-AML susceptibility and their putative upstream regulators. Gene expression profiling was performed on hematopoietic stem/progenitor cells from inbred strains of mice for which t-AML susceptibility has previously been assessed. Expression quantitative trait loci were identified by testing for association between SNP-derived haplotypes or CNVR genotypes (in cis) and expression. Genes differentially expressed between t-AML susceptible and resistant strains were identified. Differentially expressed genes that were also associated with eQTL are referred to as anchors and seeded expression network searches.