Figure 4

Anchored Susceptibility Networks. (A) Heatmap of anchored module eigengenes. For clarity, eigengene values were averaged by strain, and each module was row-normalized. Module Eigengenes are either positively (bottom half) or negatively (top half) correlated with susceptibility status. (B) Network view of anchored modules. Anchored modules are represented as nodes. Edges between modules represent network eigenegene correlation. Low and negative correlations are not shown for clarity. Edges between the 'Susceptibility' and anchored network nodes represent association between network eigengenes and susceptibility status. Node size indicates the number of response genes in the anchored network. The top super-module corresponds to the top half of the module heatmap displayed in panel A. Likewise, the bottom super-module corresponds to the bottom half of the module heatmap. (C) Module A_37, includes 10 genes on chromosome 14 located within 7 Mb of a CNVR. Green nodes represent genes with lower expression in susceptible strains, red nodes represent genes with higher expression in susceptible strains. Correlations among response genes, represented as edges, are only displayed for those relationships where the Pearson correlation > 0.5.