Figure 3

Syntenic arrangement of the human and zebrafish CYP2J locus. Human CYP2J2 metabolizes arachidonic acid to biologically active eicosanoids, some of which have vasoprotective effects. All vertebrate genomes that have been examined have at least one gene at this locus; some have many tandemly duplicated CYPs. Fish CYP2J orthologs are not members of the same subfamily, and functions may have diverged somewhat. Gene order was obtained from Ensembl 58.