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Table 3 Examples of specific enzyme and binding-protein sub-families

From: LAB-Secretome: a genome-scale comparative analysis of the predicted extracellular and surface-associated proteins of Lactic Acid Bacteria

Product LaCOG Functional domain Distribution Special features
Specific enzyme families
Subtilisin-like serine protease LaCOG02153 Subtilase family L. casei, L. delbrueckii bulgaricus,
L. johnsonii, L. lactis, S. thermophilus
PA domain (PF02225) inserted in the subtilase family domain
  LaCOG90024 Subtilase family L. acidophilus, L. casei no PA insert domain
Trans-glycosylase LaCOG01094 Transglycosylase-like domain, mainly in L.plantarum,
L.lactis, S.thermophilus
different domains for PG binding
  LaCOG01589 aggregation promoting factor related surface protein not in L.acidophilus group PG bound by LysM domain; highly conserved C-terminal domain ending in GWY
  LaCOG02932 aggregation promoting factor related surface protein only in L.delbrueckii bulgaricus,
L.plantarum, L.acidophilus group
highly conserved C-terminal domain ending in WY
  LaCOG90005 aggregation promoting factor related surface protein only in L.acidophilus group highly conserved C-terminal domain ending in GWY
Dextran sucrase LaCOG90016 glycosyl hydrolase family 70 only in Leuconostoc, L. reuteri,
O. oeni
 
Cell-surface hydrolases
alpha/beta hydrolase LaCOG01137 alpha/beta hydrolase of unknown function (DUF915) ubiquitous  
  LaCOG01138 alpha/beta hydrolase (DUF915) Ubiquitous  
  LacOG01920 alpha/beta hydrolase (DUF915) only in L. delbrueckii bulgaricus, L.plantarum , L.casei  
  LaCOG02785 alpha/beta hydrolase (DUF915) only in L.plantarum , L.casei , L.sakei  
lipase/Acyl-hydrolase LaCOG00342 GDSL-like Lipase/Acylhydrolase not in L.acidophilus group with GDSL-like motif
general cell surface hydrolase LacOG02019 cell surface hydrolase membrane-bound (putative) only in L.delbrueckii bulgaricus, L.plantarum,L.casei , L.fermentum  
  LaCOG01618 cell-surface hydrolase; only in L.plantarum , L.delbrueckii bulgaricus, P.pentosaceus  
Binding proteins
mannose-specific adhesion LaCOG01741 MUB domain, Gram positive anchor only in L.plantarum, L.delbrueckii bulgaricus, P.pentosaceus, L.acidophilus group  
collagen-binding protein LaCOG00092 Collagen binding domain, Gram positive anchor not in L.acidophilus group  
mucus-binding protein LaCOG00885 MucBP domain (Classical), Gram positive anchor not in L.acidophilus group Leucine Rich Repeat, PT repeat
  LaCOG01470 MUB domain, Gram positive anchor   many pseudogenes, most L.acidophilus group proteins have YSIRK-type signal peptide
  LacOG02280 MUB domain, Gram positive anchor only in L.acidophilus group very large, YSIRK-type signal peptide
  LaCOG03211 MUB domain, Gram positive anchor   5 of 10 are pseudogenes; YSIRK SP in L.acidophilus group members
  LacOG99309 MUB domain, Gram positive anchor only in L.acidophilus group all pseudogenes; YSIRK type signal peptide
chitin-binding protein LaCOG01300 Chitin binding domain E.faecalis, L.plantarum, L.sakei, L.lactis maybe related to niche
adherence protein LaCOG01366 von Willebrand factor type A domain, Cna protein B-type domain only in L.lactis, E.faecalis, L.citreum, L.casei