Interactions of poly-Q proteins. The Innate DB database was used to identify networks of poly-Q proteins that have been documented to physically interact with each other and relationships between the same group of proteins and transcriptional regulation of poly-Q encoding genes [28, 29]. (a) Interaction network for bovine poly-Q proteins. Black lines signify documented physical interactions while red lines refer to transcriptional regulation. Singletons representing either self-interactions or cis-acting transcriptional regulation are not shown. The cell is partitioned into cell surface, cytoplasm and nucleus. Protein-gene linkages (red) are shown at the bottom of the diagram. (b) Interaction network for the identified polymorphic bovine poly-Q encoding genes.