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Table 1 Similarity of CiaRH proteins of various streptococci to S. pneunomiae CiaRH proteins.

From: Identification of genes for small non-coding RNAs that belong to the regulon of the two-component regulatory system CiaRH in Streptococcus

Streptococcus CiaRa CiaHb CiaR recognition helixc
    VVEVYVSKVRKKL d
S. mitis B6 99 86 VVEVYVSKVRKKL
S. oralis Uo5 96 83 VVEVYVSKVRKKL
S. sanguinis SK36 88 60 VVEVYVSK I RKKL
S. agalactiae NEM316 88 51 VVEVYVSKVRKKL
S. dysgalactiae subsp. equisimilus GGS_124 84 50 VVEVYVSK I RKKL
S. equi subsp.equi 4047 80 50 VVEVYVSK I RKKL
S. equi subsp. zooepidemicus MGCS10565 80 51 VVEVYVSK I RKKL
S. gallolyticus UCN34 81 51 VVEVYVSK I RKKL
S. gordonii str. Challis substr. CH1 89 65 VVEVYVSK I RKKL
S. mutans UA159 89 55 VVEVYVSK I RKKL
S. pyogenes MGAS315 84 51 VVEVY I SK I RKKL
S. suis 05ZYH33 88 48 VVEVYVSK I RKKL
S. thermophilus CNRZ1066 86e 47e VVEVYVSK I RKKL
S. uberis 0140J 84 51 VVEVY I SK I RKKL
  OmpR E. coli SID V QI S RL R RMV
  1. a,b Similarity is given in% identical residues of S. pneumoniae R6 CiaR and CiaH, respectively.
  2. c The CiaR recognition helix was identified according to the OmpR family comparison defining DNA binding sites [37].
  3. d The recognition helix of S. pneumoniae R6 CiaR is shown for comparison. Residues deviating from CiaR R6 are underlined.
  4. e ciaR is interupted by a stop codon and was artificially fused for comparison. ciaH is interrupted by two frame shifts and was artificially fused for comparison.