Genome sequence of adherent-invasive Escherichia coli and comparative genomic analysis with other E. coli pathotypes

Nash, John HE; Villegas, Andre; Kropinski, Andrew M; Aguilar-Valenzuela, Renan; Konczy, Paulina; Mascarenhas, Mariola; Ziebell, Kim; Torres, Alfredo G; Karmali, Mohamed A; Coombes, Brian K

doi:10.1186/1471-2164-11-667

Table 4 Predicted invasion and adhesion factors in NRG857c

From: Genome sequence of adherent-invasive Escherichia coli and comparative genomic analysis with other E. coli pathotypes

Locus Tag	Protein	Ortholog in:	Function	Identity (%)	SPAAN Pad-Value
*Invasion*
NRG857_06210	putative transcriptional regulator	SMS-3-5	putative invasion gene expression up-regulator SirB	99	NA
NRG857_06250	hypothetical protein	SMS-3-5	putative invasin	93	0.44
NRG857_12485	putative intimin or invasin protein (SivH-like)	UMN026	putative intimin attaching and effacing protein or invasin protein (sivH-like)	96	NA
NRG857_13980	dinucleoside polyphosphate hydrolase	O157:H7 EDL933	putative invasion protein	100	0.12
NRG857_21885	invasion protein IbeA	SMS-3-5	invasion protein IbeA	93	0.35
*Adhesion*
NRG857_00700	putative fimbrial-like adhesin protein	UTI89	putative fimbrial-like adhesin protein	90	0.83
NRG857_00705	protein YadK	ED1a	protein yadK, putative fimbrial-like adhesin	95	0.79
NRG857_00710	putative fimbrial-like adhesin protein YadL	S88	putative fimbrial-like adhesin protein YadL	80	0.87
NRG857_00715	putative fimbrial-like adhesin protein YadM	ED1a	putative fimbrial-like adhesin protein YadM	100	0.86
NRG857_00730	predicted fimbrial-like protein	S88	putative fimbrial-like adhesin exported protein	95	0.87
NRG857_00985	lipoprotein involved with copper homeostasis and adhesion	UTI89	lipoprotein involved with copper homeostasis and adhesion	99	0.62
NRG857_01440	putative adhesin	S88	putative adhesin	95	0.91
NRG857_01490	putative autotransporter	S88	Putative adhesin; putative outer membrane autotransporter barrel	82	0.91
NRG857_03200	hypothetical protein	K-12 substr. W3110	predicted fimbrial-like adhesin protein	95	0.26
NRG857_04950	PgaD putative PGA biosynthesis protein	K-12 substr. MG1655	required for biofilm adhesin polysaccharide PGA synthesis	88	NA
NRG857_04960	PgaB outer membrane N-deacetylase	K-12 substr. MG1655	biofilm adhesin polysaccharide PGA export lipoprotein with a polysaccharide deacetylase activity needed for export	94	NA
NRG857_04965	outer membrane protein PgaA	K-12 substr. MG1655	biofilm adhesin polysaccharide PGA export, predicted OM protein	94	NA
NRG857_05015	DNA-binding transcriptional regulator CsgD	K-12 substr. DH10B	DNA-binding transcriptional regulator of adhesion determinants	87	0.25
NRG857_05965	hypothetical protein	536	Putative adhesin	100	0.59
NRG857_06960	putative autotransported outer membrane protein involved in cell adhesion	S88	putative autotransported outer membrane protein involved in cell adhesion	78	0.96
NRG857_07415	predicted fimbrial protein-like protein	UTI89	putative fimbrial adhesin FmlD precursor	93	0.90
NRG857_07420	predicted fimbrial protein-like protein	IAI1	putative fimbrial-like adhesin exported protein	89	0.74
NRG857_07425	fimbrial-like adhesin protein	APEC O1	fimbrial-like adhesin protein	98	0.74
NRG857_08345	Hypothetical protein	SE11	putative adhesin	98	0.66
NRG857_09925	hypothetical protein	SE11	putative adhesin	95	NA
NRG857_10700	putative exported fimbrial-like adhesin protein	UTI89	putative Yeh fimbiral adhesin YehA precursor	91	0.81
NRG857_10715	putative fimbrial-like adhesin protein	ED1a	putative fimbrial-like adhesin protein	89	0.82
NRG857_10720	hypothetical protein	APEC O1	putative fimbrial-like adhesin protein	100	0.33
NRG857_11325	adhesin	O157:H7 str. EC4115	putative outer membrane autotransporter adhesin	78	0.95
NRG857_11815	putative exported fimbrial-like adhesin protein	S88	putative exported fimbrial-like adhesin protein	92	0.76
NRG857_11820	fimbrial-like protein YfcQ precursor	S88	putative fimbrial-like adhesin exported protein	99	0.83
NRG857_11825	hypothetical protein	S88	putative fimbrial-like adhesin exported protein	96	0.57
NRG857_11840	putative fimbrial-like adhesin protein	S88	fimbrial-like adhesin protein	76	0.78
NRG857_15155	putative fimbrial protein	S88	putative fimbrial-like adhesin protein	100	0.75
NRG857_15170	putative fimbrial adhesin	UTI89	putative Yqi fimbrial adhesin	95	0.84
NRG857_16975	putative fimbrial-like adhesin protein AufG	ED1a	putative fimbrial-like adhesin protein AufG	94	0.62
NRG857_17635	LpfE protein precursor	O26:H11 str. 11368	putative fimbrial adhesin protein	86	0.68
NRG857_17920	putative haemagglutinin/Invasin	CFT073	putative adhesin	87	0.98
NRG857_21795	type 1 fimbiral adhesin FimH	APEC O1	type 1 fimbrial adhesin FimH	100	0.95

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