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Table 1 Gene ontology (GO) categories significantly overrepresented in Holstein CNV.

From: Analysis of copy loss and gain variations in Holstein cattle autosomes using BeadChip SNPs

  Human ref. gene # CNV gene # Expected P value
Pathways
Wnt signalling pathway1 348 26 10.80 0.00878
Alzheimer disease-presenilin pathway1 143 12 4.44 0.344
Cadherin signalling pathway1 168 13 5.21 0.459
Biological Process
Chemosensory perception2 207 37 6.42 8.75E-15
Olfaction2 198 36 6.14 1.88E-14
Sensory perception2 506 48 15.70 7.16E-10
G-protein-mediated signalling2 834 66 25.87 2.10E-09
Cell surface receptor-mediated signal transduction2 1638 92 50.82 6.01E-06
Signal transduction2 3406 156 105.67 1.26E-05
Transport3 1306 63 40.52 0.014
Molecular Function
G-protein-coupled receptor2 571 50 17.72 2.18E-08
Receptor2 1512 82 46.91 2.77E-05
Cell-adhesion molecule1 395 24 12.25 0.0511
Cadherin1 111 11 3.44 0.14
Transporter3 648 32 20.10 0.229
  1. NCBI list of 25,431 Homo sapiens genes were compared to the list of 789 genes orthologous to the CNV gene content (Additional file 3) using PANTHER. 1,2,3 denote categories that are associated with overrepresentation of gene families for cadherins, olfactory receptors and transporters, respectively. The full version of this table is provided in Additional file 4.