Figure 5

Comparisons of individual expression profiles. (A.) Transcription factors Dbp and Tef are controlled by the circadian clock-associated suprachiasmatic nucleus and exhibit conserved, sex-specific life cycle profiles. (B.) Cux2 functions as a female-specific repressor and putatively represses Cyp4a8 expression in females but not males in an age-dependent manner. (C.) Cdh17 exhibits male-specific predominance in expression from 8 weeks onward, while Stat3 shows female-specific predominance transiently at 15 weeks. (D.) Both Por and Mgmt exhibit trends of increasing expression during the second year of the rat life cycle and are involved in xenobiotic metabolism and DNA damage repair, respectively. (E.) Early developmental transition between Igf2-predominance at 2 weeks to Igf1-predominance by 6 and 8 weeks in the liver is shown at the expression level. The right Y-axes present in panels C and E represent data for Stat3 and Igf1, respectively, to show differences in scale.