From: Age and sex dependent changes in liver gene expression during the life cycle of the rat
 |  |  |  |  |  |  | Cluster** | |
---|---|---|---|---|---|---|---|---|
Category | Pathway | Entrez GeneID | Gene Symbol | P-value* (AGE) | P-value* (SEX) | P-value* (AGE^SEX) | Female | Male |
DNA Damage Repair | BER | 304577 | Ung | 0.0026 | 0 | 0.2116 | 1 | 1 |
 |  | 25332 | Mgmt | 0.778 | 0 | 0.0006 | 23 | 11 |
 | MMR | 294252 | Msh5 | 0.3511 | 0.0043 | 0.6288 | 9 | 23 |
 | NER | 298074 | Xpa | 0.0002 | 0 | 0.7036 | 11 | 24 |
 |  | 59102 | Rpa2 | 0.5979 | 0.0042 | 0.0102 | 14 | 2 |
 |  | 81513 | Lig1 | 0.459 | 0 | 0.0009 | 6 | 2 |
 | Other | 85472 | Polg | 0.0001 | 0.0022 | 0.1838 | 2 | 30 |
 |  | 59294 | Pold1 | 0.3243 | 0 | 0 | 14 | 2 |
 |  | 316344 | Rev1 | 0.0007 | 0 | 0.0009 | 15 | 2 |
 |  | 84490 | Fen1 | 0.0339 | 0 | 0.001 | 6 | 2 |
 |  | 308755 | Blm | 0.0008 | 0 | 0.0021 | 7 | 2 |
 |  | 309595 | Mdc1 | 0.8699 | 0 | 0.0564 | 29 | 29 |
Xenobiotic Metabolism | Phase 1 | 24300 | Cyp2b1 | 0.1891 | 0 | 0.3345 | 12 | 10 |
 |  | 378476 | Cyp2c11 | 0 | 0 | 0 | 10 | 25 |
 |  | 171521 | Cyp2c13 | 0 | 0 | 0 | 29 | 10 |
 |  | 266682 | Cyp3a2 | 0 | 0 | 0 | 2 | 29 |
 |  | 252931 | Cyp3a18 | 0 | 0 | 0 | 21 | 25 |
 |  | 170509 | Cyp3a62 | 0 | 0 | 0 | 23 | 11 |
 |  | 266674 | Cyp4a8 | 0 | 0 | 0 | 1 | 25 |
 | Phase 2 | 24422 | Gsta2 | 0.0189 | 0 | 0 | 1 | 8 |
 |  | 24423 | Gstm1 | 0 | 0 | 0 | 12 | 8 |
 |  | 24424 | Gstm2 | 0 | 0 | 0 | 1 | 8 |
 |  | 24862 | Ugt2b | 0.3287 | 0.006 | 0.0082 | 9 | 25 |
 | Phase 3 | 25303 | Abcc2 | 0 | 0 | 0.2455 | 8 | 8 |
 |  | 140668 | Abcc3 | 0 | 0 | 0 | 21 | 6 |
 |  | 83500 | Slc22a8 | 0 | 0 | 0 | 5 | 13 |
 |  | 0 | Slco1b3 | 0 | 0 | 0.0053 | 1 | 11 |
 |  | 117048 | Cdh17 | 0 | 0 | 0 | 4 | 25 |
 |  | 25027 | Slc16a1 | 0 | 0 | 0.0207 | 21 | 2 |
 |  | 295356 | Slc16a4 | 0 | 0 | 0 | 21 | 25 |
Oxidative Stress Response | Nrf2 | 25315 | Ephx1 | 0.0091 | 0 | 0.0458 | 1 | 1 |
 | Pathway | 25256 | Fmo1 | 0.1169 | 0.0008 | 0 | 6 | 10 |
 |  | 113894 | Sqstm1 | 0.1126 | 0 | 0.0394 | 1 | 1 |
 |  | 24451 | Hmox1 | 0.1788 | 0 | 0.182 | 14 | 14 |
 |  | 29292 | Ftl | 0.5177 | 0 | 0.2465 | 12 | 12 |
 |  | 24786 | Sod1 | 0.0001 | 0 | 0.3873 | 8 | 1 |
 |  | 24248 | Cat | 0.0035 | 0 | 0.0148 | 1 | 19 |
 |  | 58819 | Txnrd1 | 0.7899 | 0.0001 | 0.5142 | 12 | 10 |
 |  | 291796 | Usp14 | 0.0053 | 0 | 0.0001 | 21 | 29 |