BMC Genomics

Table 1 Supervised analysis of differentially expressed genes from specified pathways

From: Age and sex dependent changes in liver gene expression during the life cycle of the rat

							Cluster**
Category	Pathway	Entrez GeneID	Gene Symbol	P-value* (AGE)	P-value* (SEX)	P-value* (AGE^SEX)	Female	Male
DNA Damage Repair	BER	304577	Ung	0.0026	0	0.2116	1	1
		25332	Mgmt	0.778	0	0.0006	23	11
	MMR	294252	Msh5	0.3511	0.0043	0.6288	9	23
	NER	298074	Xpa	0.0002	0	0.7036	11	24
		59102	Rpa2	0.5979	0.0042	0.0102	14	2
		81513	Lig1	0.459	0	0.0009	6	2
	Other	85472	Polg	0.0001	0.0022	0.1838	2	30
		59294	Pold1	0.3243	0	0	14	2
		316344	Rev1	0.0007	0	0.0009	15	2
		84490	Fen1	0.0339	0	0.001	6	2
		308755	Blm	0.0008	0	0.0021	7	2
		309595	Mdc1	0.8699	0	0.0564	29	29
Xenobiotic Metabolism	Phase 1	24300	Cyp2b1	0.1891	0	0.3345	12	10
		378476	Cyp2c11	0	0	0	10	25
		171521	Cyp2c13	0	0	0	29	10
		266682	Cyp3a2	0	0	0	2	29
		252931	Cyp3a18	0	0	0	21	25
		170509	Cyp3a62	0	0	0	23	11
		266674	Cyp4a8	0	0	0	1	25
	Phase 2	24422	Gsta2	0.0189	0	0	1	8
		24423	Gstm1	0	0	0	12	8
		24424	Gstm2	0	0	0	1	8
		24862	Ugt2b	0.3287	0.006	0.0082	9	25
	Phase 3	25303	Abcc2	0	0	0.2455	8	8
		140668	Abcc3	0	0	0	21	6
		83500	Slc22a8	0	0	0	5	13
		0	Slco1b3	0	0	0.0053	1	11
		117048	Cdh17	0	0	0	4	25
		25027	Slc16a1	0	0	0.0207	21	2
		295356	Slc16a4	0	0	0	21	25
Oxidative Stress Response	Nrf2	25315	Ephx1	0.0091	0	0.0458	1	1
	Pathway	25256	Fmo1	0.1169	0.0008	0	6	10
		113894	Sqstm1	0.1126	0	0.0394	1	1
		24451	Hmox1	0.1788	0	0.182	14	14
		29292	Ftl	0.5177	0	0.2465	12	12
		24786	Sod1	0.0001	0	0.3873	8	1
		24248	Cat	0.0035	0	0.0148	1	19
		58819	Txnrd1	0.7899	0.0001	0.5142	12	10
		291796	Usp14	0.0053	0	0.0001	21	29

*Two-way ANOVA results concerning AGE and SEX, n = 5, on normalized intensity values. "0" indicates p-values less than 1 × 10-6. **K-means cluster analysis of expression profiles, agglomerative clustering, (Figure 3)

Back to article page

ISSN: 1471-2164

Contact us

Submission enquiries: bmcgenomics@biomedcentral.com
General enquiries: ORSupport@springernature.com