Table 1 Changes in transcripts for genes implicated in major signalling pathways between Pax3-GFP/+ samples from somites and/or limbs of gain of function Pax3PAX3-FKHR/GFP and control Pax3GFP/+ embryos: UP (bold), DOWN (italics)
From: Transcriptome analyses based on genetic screens for Pax3 myogenic targets in the mouse embryo
| Â | Â | Pax3PAX3-FKHR/GFPvs Pax3GFP/+ | |
|---|---|---|---|
RTK | FGF | Ligands/Extracellular matrix | FGF5, FGF12, Sulfatase1 |
| Â | Â | Receptors | Fgfr4, Fgfr3 |
| Â | Â | Intracellular components | Dusp4, Fap |
| Â | Â | Inhibitors | Spry1, Spry4, Ing5, Spred1 |
| Â | Â | Transcriptional components | Etv1, Etv2 |
| Â | IGF | Ligand | Igf1 |
| Â | PDGF | Ligand | Pdgfc |
| Â | Â | Effector (target) | Csrp1 (Axud1) |
| Â | Met | Receptor | c-Met |
| Â | Eph | Ligands | EphrinA5, EphrinB1 |
| Â | Â | Receptors | EphA7, EphA3 |
Shh | Ligands/Extracellular matrix | Sulfatase1 | |
| Â | Â | Inhibitors | Hhip |
| Â | Â | Transcriptional components | Zic1 |
Wnt | Ligands/Extracellular matrix | Wnt16, Sulfatase1 | |
| Â | Â | Intracellular components | Siah2, Diversin (Ankrd6) |
| Â | Â | Inhibitors | Sfrp3 (Frzb1), Dkk1, Dkk2, Diversin, Wif1, Csrp1 (Axud1) |
| Â | Â | Transcriptional components | TCF15, TCF7/2 , Nkd2 |
Integrins | Ligands | Lama2 | |
|  |  | Intracellular components | Itgβ1bp2 |
|  |  | Receptors | Itgβ6, Itgβ8 |
Cytokines | Ligands | CXC15, CXC12, Cxcl14, Cxcl5 | |
| Â | Â | Intracellular components | CXCR7, Crlf1 |
| Â | Â | Inhibitors | Soc3 |
Notch | Ligands | Dll1, Dll3 | |
| Â | Â | Inhibitors | Fhl1 (Kyot2) |
| Â | Â | Transcriptional components | Hes1 |
TGFβ/BMP | Ligands | BMP5, TGFβ2, TGFβinduced, Thbs1 | |
| Â | Â | Inhibitors | Chordin-like1, Follistatin, Gremlin |